| Chemical & Physical Properties | |
|---|---|
| CAS Number | 943319-70-8 |
| Catalog No. | 2A-1169273 |
| Chinese Name | 帕纳替尼 |
| Synonyms | Iclusig; UNII:4340891KFS; Ponatinib; AP24534 |
| Molecular Formula | C29H27F3N6O |
| Molecular Weight | 532.560 |
| Density | 1.3±0.1 g/cm3 |
| Melting Point | >160 °C |
| Storage Condition | -20°C |
| Application | Ponatinib is a potent, orally available, multi-target kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1 and Src, respectively. |
| HTC | 29335990 |
| PubChem ID | 49848164 |
| SMILES | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 |
| InChI | InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39) |
| InChI Key | PHXJVRSECIGDHY-UHFFFAOYSA-N |
| Transport Info | Product Name: Ponatinib (AP24534) |
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| di(2-Hydroxy Atorvastatin) CalciuM Salt | 265989-46-6 | 2A-1169254 |
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