CAS Number144143-96-4
SynonymsMFCD08141807; Eprosartan mesylate; Eprosartan Monomethanesulfonate SKF-108566J Teveten; Eprosartan (mesylate)
Molecular FormulaC24H28N2O7S2
Molecular Weight520.618
Density1.26 g/cm3
Boiling Point660.6ºC
Melting Point248 °C
AppearanceA white to off-white powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 144143-96-4 |
| Catalog No. | 2A-1169229 |
| Chinese Name | 甲磺酸依普罗沙坦 |
| Synonyms | MFCD08141807; Eprosartan mesylate; Eprosartan Monomethanesulfonate SKF-108566J Teveten; Eprosartan (mesylate) |
| Molecular Formula | C24H28N2O7S2 |
| Molecular Weight | 520.618 |
| Density | 1.26 g/cm3 |
| Boiling Point | 660.6ºC |
| Melting Point | 248 °C |
| Appearance | A white to off-white powder |
| Water Solubility | Water solubility: insoluble; soluble in: ethanol |
| Storage Condition | room temp |
| Application | Eprosartan is a non-peptide angiotensin II receptor antagonist with IC50s of 9.2 and 3.9 nM in mouse and human adrenocortical membranes, respectively. |
| HTC | 2934999090 |
| PubChem ID | 7849144 |
| SMILES | CCCCc1ncc(C=C(Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1.CS(=O)(=O)O |
| InChI | InChI=1S/C23H24N2O4S.CH4O3S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27;1-5(2,3)4/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29);1H3,(H,2,3,4)/b18-12+; |
| InChI Key | DJSLTDBPKHORNY-XMMWENQYSA-N |
| Use of | Properties Name eprosartan methanesulfonate Synonym More Synonyms Eprosartan mesylate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease References [1]. Qian, J.J., et al., Eprosartan mesylate, an angiotensin II receptor antagonist. Acta Crystallogr Sect E Struct Rep Online, 2011. 67(Pt 4): p. o770-1. [2]. Edwards, R.M., et al., Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther, 1992. 260(1): p. 175-81. [4]. Punzi, H.A. and C.F. Punzi, Once-daily eprosartan mesylate in the treatment of elderly patients with isolated systolic hypertension: data from a 13-week double-blind, placebo-controlled, parallel, multicenter study. J Hum Hypertens, 2004. 18(9): p. 655-61 [5]. Martynov, M., et al., [Eprosartan mesylate in controlling of blood pressure in patients with ischemic stroke]. Zh Nevrol Psikhiatr Im S S Korsakova, 2002. 102(4): p. 26-30. Chemical & Physical Properties Molecular Formula C24H28N2O7S2 Exact Mass 520.133789 PSA 183.41000 LogP 5.32920 InChIKey DJSLTDBPKHORNY-XMMWENQYSA-N Storage condition room temp Safety Information Signal Word Warning Hazard Statements H315-H319 Precautionary Statements P305 + P351 + P338 Hazard Codes Xi Safety Phrases 26 RIDADR NONH for all modes of transport HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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