CAS Number64439-81-2
Synonyms10-Hydroxycamptothecin; MFCD00274425; Camptothecin, 10-hydroxy; EINECS 244-759-8; 10-hydroxy-Camptothecin; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Molecular FormulaC20H16N2O5
Molecular Weight364.351
Purity98%
Density1.6±0.1 g/cm3
Boiling Point820.7±65.0 °C at 760 mmHg
Melting Point230-237°C
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 64439-81-2 |
| Catalog No. | 2A-1168296 |
| Chinese Name | 10-羟基喜树碱 |
| Synonyms | 10-Hydroxycamptothecin; MFCD00274425; Camptothecin, 10-hydroxy; EINECS 244-759-8; 10-hydroxy-Camptothecin; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Molecular Formula | C20H16N2O5 |
| Molecular Weight | 364.351 |
| Purity | 98 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 820.7±65.0 °C at 760 mmHg |
| Melting Point | 230-237°C |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | (±)-10-Hydroxycamptothecin is an alkaloid isolated from Camptotheca acacia, which can inhibit the activity of topoisomerase I and has broad-spectrum anti-tumor activity. |
| HTC | 2934999090 |
| PubChem ID | 6365931 |
| SMILES | CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(O)ccc3nc2-1 |
| InChI | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3 |
| InChI Key | HAWSQZCWOQZXHI-UHFFFAOYSA-N |
| Use of | (±)-10-Hydroxycamptothecin, an indole alkaloid isolated from Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity. Properties Name 10-Hydroxycamptothecin Synonym More Synonyms (S)-10-hydroxycamptothecin Biological Activity Description (±)-10-Hydroxycamptothecin, an indole alkaloid isolated from Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Topoisomerase I References [1]. Liu SY, et al. Interaction of several nucleoside triphosphate analogues and 10-hydroxycamptothecin with human DNA topoisomerases. Cancer Res. 1989 Mar 15;49(6):1366-70. [2]. Ping YH, et al. Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. Oncol Rep. 2006 May;15(5):1273-9. [3]. Fan J, et al. Detection of apoptosis exposed to 10-hydroxycamptothecin in T24 human urinary bladder cancer cells. Zhonghua Wai Ke Za Zhi. 1999 Jan;37(1):57-9. Chemical & Physical Properties Molecular Formula C20H16N2O5 Exact Mass 364.105927 PSA 101.65000 Index of Refraction 1.777 InChIKey HAWSQZCWOQZXHI-UHFFFAOYSA-N Safety Information Hazard Codes Xi Safety Phrases S26-S36 WGK Germany 3 HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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