| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1374639-75-4 |
| Catalog No. | 2A-1168289 |
| Chinese Name | LEE011 琥珀酸盐 |
| Synonyms | MFCD28167746; LEE011-BBA; Ribociclib succinate; UNII:BG7HLX2919; LEE011 (succinate); LEE011 succinate; Ribociclib |
| Molecular Formula | C27H36N8O5 |
| Molecular Weight | 552.625 |
| Storage Condition | Room temperature, store in inert gas |
| Application | Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is less than 1000-fold active against the cyclin B/CDK1 complex. |
| PubChem ID | 136336631 |
| SMILES | CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1.O=C(O)CCC(=O)O |
| InChI | InChI=1S/C23H30N8O.C4H6O4/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1-2H2,(H,5,6)(H,7,8) |
| InChI Key | NHANOMFABJQAAH-UHFFFAOYSA-N |
| Transport Info | Product name: LEE011 succinate |
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