CAS Number2424-92-2
Synonymseicosadioic acid; Icosanedioic acid; 1,18-Octadecanedicarboxylic acid; eicosa-1,20-dioic acid; eicosane diacid; 1,20-icosanedioic acid; Eicossandioic acid; eicosandioic acid; Eicosanedioic acid; MFCD00059627; octadecane-1,18-dicarboxylic acid
Molecular FormulaC20H38O4
Molecular Weight342.513
Purity98.00%
Density1.0±0.1 g/cm3
Boiling Point504.1±23.0 °C at 760 mmHg
Melting Point127ºC
AppearancePowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2424-92-2 |
| Catalog No. | 2A-1167647 |
| Chinese Name | 二十烷二酸 |
| Synonyms | eicosadioic acid; Icosanedioic acid; 1,18-Octadecanedicarboxylic acid; eicosa-1,20-dioic acid; eicosane diacid; 1,20-icosanedioic acid; Eicossandioic acid; eicosandioic acid; Eicosanedioic acid; MFCD00059627; octadecane-1,18-dicarboxylic acid |
| Molecular Formula | C20H38O4 |
| Molecular Weight | 342.513 |
| Purity | 98.00 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 504.1±23.0 °C at 760 mmHg |
| Melting Point | 127ºC |
| Appearance | Powder |
| Water Solubility | Slightly soluble in water. |
| Storage Condition | Store at room temperature, away from light and hea |
| Application | Eicosadienoic acid is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADC). Eicosanedioic acid is also an alkyl chain-based PROTAC linker that can be used in the synthesi |
| HTC | 2917190090 |
| PubChem ID | 8197302 |
| SMILES | O=C(O)CCCCCCCCCCCCCCCCCCC(=O)O |
| InChI | InChI=1S/C20H38O4/c21-19(22)17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(23)24/h1-18H2,(H,21,22)(H,23,24)/p-2 |
| InChI Key | JJOJFIHJIRWASH-UHFFFAOYSA-N |
| Bioactivity | Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 504.1±23.0 °C at 760 mmHg Melting Point 127ºC Molecular Formula C20H38O4 Molecular Weight 342.513 Flash Point 272.8±19.1 °C Exact Mass 342.277008 PSA 74.60000 LogP 7.18 Appearance of Characters Powder Vapour Pressure 0.0±2.8 mmHg at 25°C Index of Refraction 1.474 InChIKey JJOJFIHJIRWASH-UHFFFAOYSA-N SMILES O=C(O)CCCCCCCCCCCCCCCCCCC(=O)O Water Solubility Slightly soluble in water. |
| Use of | Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis Properties Name eicosanedioic acid Synonym More Synonyms Icosanedioic acid Biological Activity Description Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C20H38O4 Exact Mass 342.277008 PSA 74.60000 Appearance of Characters Powder Index of Refraction 1.474 InChIKey JJOJFIHJIRWASH-UHFFFAOYSA-N SMILES O=C(O)CCCCCCCCCCCCCCCCCCC(=O)O Water Solubility Slightly soluble in water. |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Eicosanedioic acid Modification number: 5 |
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