CAS Number54-47-7
SynonymsPyridoxal-5-monophosphate; (4-Formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl dihydrogen phosphate; Phosphate, Pyridoxal; (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate; (4-Formyl-5-hydroxy-6-methyl-3-pyridinyl)methyldihydrogen-phosphat; Aderoxal; EINECS 200-208-3; (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyldihydrogen-phosphat; Vitamin B6 phosphate; Pyridoxal 5-phosphate; Pyridoxal phosphate; MFCD00006333; Pyridoxyl phosphate; Pyridoxal 5'-phosphic acid; Isonicotinaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methyl-, 5-(dihydrogen phosphate); 3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde
Molecular FormulaC8H10NO6P
Molecular Weight247.14
Purity98.00%
Density1.6±0.1 g/cm3
Boiling Point565.7±60.0 °C at 760 mmHg
Melting Point140-143ºC
Appearanceliquid
EINECS200-208-3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54-47-7 |
| Catalog No. | 2A-9016665 |
| Chinese Name | 磷酸吡哆醛 |
| Synonyms | Pyridoxal-5-monophosphate; (4-Formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl dihydrogen phosphate; Phosphate, Pyridoxal; (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate; (4-Formyl-5-hydroxy-6-methyl-3-pyridinyl)methyldihydrogen-phosphat; Aderoxal; EINECS 200-208-3; (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyldihydrogen-phosphat; Vitamin B6 phosphate; Pyridoxal 5-phosphate; Pyridoxal phosphate; MFCD00006333; Pyridoxyl phosphate; Pyridoxal 5'-phosphic acid; Isonicotinaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methyl-, 5-(dihydrogen phosphate); 3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde |
| Molecular Formula | C8H10NO6P |
| Molecular Weight | 247.14 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 565.7±60.0 °C at 760 mmHg |
| Melting Point | 140-143ºC |
| Appearance | liquid |
| Storage Condition | This product should be sealed at 4 ℃ to dry and ke |
| Application | Pyridoxal phosphate is the active form of vitamin B6 that inhibits the activity of reverse transcriptases and is used in the study of tardive dyskinesia. |
| EINECS | 200-208-3 |
| HTC | 2936250000 |
| MDL Number | MFCD00006333 |
| SMILES | [P](=O)(OCc1cnc(c(c1C=O)O)C)(O)O |
| InChI | 1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) |
| InChI Key | NGVDGCNFYWLIFO-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Safety Description | S22;S24/25 |
| MSDS | msds/16665_1_54_47_7.pdf |
| Bioactivity | Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia. Related Catalog Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Neurological Disease Natural Products >> Others Target Human Endogenous Metabolite In Vitro Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Pyridoxal phosphate results in an imnediate reduction in the rate of DNA synthesis[1]. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost[2]. References [1]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7. [2]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 565.7±60.0 °C at 760 mmHg Melting Point 140-143ºC Molecular Formula C8H10NO6P Molecular Weight 247.142 Flash Point 296.0±32.9 °C Exact Mass 247.024567 PSA 126.76000 LogP -0.52 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.641 InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N SMILES Cc1ncc(COP(=O)(O)O)c(C=O)c1O Storage condition −20°C |
| Use of | Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia. Properties Name pyridoxal 5'-phosphate Synonym More Synonyms Pyridoxal phosphate Biological Activity Description Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia. Related Catalog Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Neurological Disease Natural Products >> Others Human Endogenous Metabolite In Vitro Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Pyridoxal phosphate results in an imnediate reduction in the rate of DNA synthesis[1]. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost[2]. References [1]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7. [2]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5. Chemical & Physical Properties Molecular Formula C8H10NO6P Exact Mass 247.024567 PSA 126.76000 LogP -0.52 Index of Refraction 1.641 InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N SMILES Cc1ncc(COP(=O)(O)O)c(C=O)c1O |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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