CAS Number15489-90-4
Synonyms[Dihydrogen 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]hydroxyiron; ferriporphyrin hydroxide; heme; BOVINE HEMIN; ferriheme hydroxide; Hydroxy[3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]iron; ferrihemate; Hematin porcine; Hematin; haem; MFCD00011615; HAEMATIN; hydroxyhemin; phenodin; ferriheme; EINECS 239-518-9
Molecular FormulaC34H33FeN4O5
Molecular Weight633.495
Purity98.00%
Boiling Point1128.5ºC at 760 mmHg
Melting Point180ºC
AppearanceDark crystals with metallic luster
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 15489-90-4 |
| Catalog No. | 2A-1166623 |
| Chinese Name | 羟高铁血红素 |
| Synonyms | [Dihydrogen 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]hydroxyiron; ferriporphyrin hydroxide; heme; BOVINE HEMIN; ferriheme hydroxide; Hydroxy[3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]iron; ferrihemate; Hematin porcine; Hematin; haem; MFCD00011615; HAEMATIN; hydroxyhemin; phenodin; ferriheme; EINECS 239-518-9 |
| Molecular Formula | C34H33FeN4O5 |
| Molecular Weight | 633.495 |
| Purity | 98.00 |
| Boiling Point | 1128.5ºC at 760 mmHg |
| Melting Point | 180ºC |
| Appearance | Dark crystals with metallic luster |
| Storage Condition | Store sealed and dry at 4°C. |
| Application | Heme is an iron-containing porphyrin that inhibits the activity of coagulation factors and the dissolution of fibrin clots by binding to and inactivating hemostatic proteins [1]. Heme can be used in t |
| PubChem ID | 198961111 |
| SMILES | C=CC1=C(C)c2cc3[n-]c(cc4nc(cc5[n-]c(cc1n2)c(C)c5C=C)C(C)=C4CCC(=O)O)c(CCC(=O)O)c3C.O.[Fe+2] |
| InChI | InChI=1S/C34H34N4O4.Fe.H2O/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);;1H2/q;+3;/p-3 |
| InChI Key | CODDGSIFXYHHJO-UHFFFAOYSA-L |
| MSDS | msds/166628_2_15489_90_4.pdf |
| Bioactivity | Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease In Vitro Hematin (0.01 mg/ml) inhibits the clotting of bovine fibrinogen (1.3 to 2.6 mg/ml) by bovine thrombin (0.12 U/ml) and inhibits the hydrolysis of a synthetic substrate by human thrombin[2]. Hematin (0.035 mg/ml) reduces VIII:C activity from 0.88 to 0.40 U/ml[2]. Hematin (0.05 mg/ml) inhibits the activation of VIII:C by thrombin (0.04 U/ml)[2]. Hematin (0.09 mg/ml) inhibits the hydrolysis of a synthetic substrate by plasmin[2]. In Vivo Hematin (i.v.; single injection) suppressed porphyrin production in SD rat (weighing 160-205 g)[4]. References [1]. Siegert SW, et al. Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. Adv Ther. 2008 Sep;25(9):842-57. [2]. Green D, et al. The inactivation of hemostatic factors by hematin. J Lab Clin Med. 1983;102: 361-369. [3]. Amin ML, et al. Development of hematin conjugated PLGA nanoparticle for selective cancer targeting. Eur J Pharm Sci. 2016 Aug 25;91:138-43. [4]. Goetsch C, et al. Instability of hematin used in the treatment of acute hepatic porphyria. N Engl J Med. 1986;315: 235-238. [5]. Quadros HC, et al. The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs. Pharmaceuticals (Basel). 2022;15(1):60. Published 2022 Jan 4. Chemical & Physical Properties Boiling Point 1128.5ºC at 760 mmHg Melting Point 180ºC Molecular Formula C34H33FeN4O5 Molecular Weight 633.495 Flash Point 636.3ºC Exact Mass 633.180054 PSA 129.41000 LogP 3.43290 Vapour Pressure 0mmHg at 25°C InChIKey CODDGSIFXYHHJO-UHFFFAOYSA-L SMILES C=CC1=C(C)c2cc3[n-]c(cc4nc(cc5[n-]c(cc1n2)c(C)c5C=C)C(C)=C4CCC(=O)O)c(CCC(=O)O)c3C.O.[Fe+2] Storage condition 2~8°C |
| Use of | Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5]. Properties Articles33 Name hematin Synonym More Synonyms Hematin Biological Activity Description Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Siegert SW, et al. Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. Adv Ther. 2008 Sep;25(9):842-57. [2]. Green D, et al. The inactivation of hemostatic factors by hematin. J Lab Clin Med. 1983;102: 361-369. [3]. Amin ML, et al. Development of hematin conjugated PLGA nanoparticle for selective cancer targeting. Eur J Pharm Sci. 2016 Aug 25;91:138-43. [4]. Goetsch C, et al. Instability of hematin used in the treatment of acute hepatic porphyria. N Engl J Med. 1986;315: 235-238. [5]. Quadros HC, et al. The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs. Pharmaceuticals (Basel). 2022;15(1):60. Published 2022 Jan 4. Chemical & Physical Properties Molecular Formula C34H33FeN4O5 Exact Mass 633.180054 PSA 129.41000 LogP 3.43290 InChIKey CODDGSIFXYHHJO-UHFFFAOYSA-L |
| Transport Info | Product Name: Hydroxyheme |
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