CAS Number329-56-6
Synonyms[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium chloride; (-)noradrenaline hydrochloride; L-ARTERENOL HYDROCHLORIDE; 1-(3,4-dihydroxyphenyl)-2-aminoethanol hydrochloride; (-)-norepinephrine hydrochloride; (R)-(-)-noradrenaline hydrochloride; [2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]azanium chloride; 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, hydrochloride (1:1); Levophed hydrochloride; L-NOREPINEPHRINE HYDROCHLORIDE; (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol hydrochloride; 4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol hydrochloride (1:1); Aktamin hydrochloride; levophedhydrochloride; 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol hydrochloride (1:1); (-)-ARTERENOL HYDROCHLORIDE; NOREPINEPHRINE HYDROCHLORIDE; aktaminhydrochloride; Norepinephrine (hydrochloride)
Molecular FormulaC8H12ClNO3
Molecular Weight205.639
Purity98.00%
Density1.397g/cm3
Boiling Point442.6ºC at 760mmHg
Melting Point-150ºC (dec.)
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 329-56-6 |
| Catalog No. | 2A-1166606 |
| Chinese Name | 去甲肾上腺素盐酸盐 |
| Synonyms | [2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium chloride; (-)noradrenaline hydrochloride; L-ARTERENOL HYDROCHLORIDE; 1-(3,4-dihydroxyphenyl)-2-aminoethanol hydrochloride; (-)-norepinephrine hydrochloride; (R)-(-)-noradrenaline hydrochloride; [2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]azanium chloride; 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, hydrochloride (1:1); Levophed hydrochloride; L-NOREPINEPHRINE HYDROCHLORIDE; (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol hydrochloride; 4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol hydrochloride (1:1); Aktamin hydrochloride; levophedhydrochloride; 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol hydrochloride (1:1); (-)-ARTERENOL HYDROCHLORIDE; NOREPINEPHRINE HYDROCHLORIDE; aktaminhydrochloride; Norepinephrine (hydrochloride) |
| Molecular Formula | C8H12ClNO3 |
| Molecular Weight | 205.639 |
| Purity | 98.00 |
| Density | 1.397g/cm3 |
| Boiling Point | 442.6ºC at 760mmHg |
| Melting Point | -150ºC (dec.) |
| Storage Condition | 2-8℃ |
| Packaging | III |
| Application | Norepinephrine hydrochloride is a β1-selective adrenergic receptor agonist with an EC50 value of 5.37 μM. |
| HTC | 2922509090 |
| PubChem ID | 16776771 |
| SMILES | Cl.NCC(O)c1ccc(O)c(O)c1 |
| InChI | InChI=1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H |
| InChI Key | FQTFHMSZCSUVEU-QRPNPIFTSA-N |
| Hazard Symbols | 6.1(b) |
| Use of | Norepinephrine hydrochloride is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. Properties Name l-noradrenaline hydrochloride Synonym More Synonyms Norepinephrine hydrochloride Biological Activity Description Norepinephrine hydrochloride is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cardiovascular Disease EC50: 5.37 μM (β1-selective adrenergic receptor)[1] In Vitro Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2]. References [1]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [2]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. Chemical & Physical Properties Exact Mass 205.050568 PSA 86.71000 LogP 1.59220 InChIKey FQTFHMSZCSUVEU-QRPNPIFTSA-N Storage condition 2-8℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, hydrochloride, (-)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : Z1YQR CQ DQ &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 180,155,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 180,155,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraduodenal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 180,155,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : Safety Information Hazard Codes T: Toxic; Risk Phrases R25 Packaging Group III Hazard Class 6.1(b) HS Code 2922509090 Synthetic Route Total: 1 Page N-{{7-[bis(carb... CAS#:1031721-23-9 CAS#:876275-37-5 Carbon dioxide CAS#:124-38-9 Norepinephrine ... CAS#:329-56-6 Literature: Hagen, Volker; Dekowski, Brigitte; Kotzur, Nico; Lechler, Ralf; Wiesner, Burkhard; Briand, Benoit; Beyermann, Michael Chemistry - A European Journal, 2008 , vol. 14, # 5 p. 1621 - 1627 |
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