CAS Number50-42-0
SynonymsTrasentin Hydrochloride; MFCD00242658; Benzeneacetic acid, α-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 2-Diethylaminoethyl diphenylacetate hydrochloride; Adiphenine HCl; Benzeneacetic acid, α-phenyl-, 2- (diethylamino)ethyl ester, hydrochloride; Trasentine; Diphenylacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; EINECS 200-036-9; 2-(Diethylamino)ethyl diphenylacetate hydrochloride (1:1); Lunal; Diphenylacetyldiethylaminoethanol Hydrochloride; a-Phenylbenzeneacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2-(diethylamino)ethyl 2,2-diphenylacetate,hydrochloride; Acetic acid, diphenyl-, 2- (diethylamino)ethyl ester hydrochloride; Adiphenine Hydrochloride; 2-(Diethylamino)ethyl Diphenylacetate Hydrochloride; Adiphenine (hydrochloride)
Molecular FormulaC20H26O2N1Cl1
Molecular Weight347.88
Purity98.00%
Boiling Point423ºC at 760 mmHg
Melting Point71-74 °C(lit.)
AppearanceWhite or almost white powder
EINECS200-036-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50-42-0 |
| Catalog No. | 2A-9016553 |
| Chinese Name | 阿地芬宁盐酸盐 |
| Synonyms | Trasentin Hydrochloride; MFCD00242658; Benzeneacetic acid, α-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 2-Diethylaminoethyl diphenylacetate hydrochloride; Adiphenine HCl; Benzeneacetic acid, α-phenyl-, 2- (diethylamino)ethyl ester, hydrochloride; Trasentine; Diphenylacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; EINECS 200-036-9; 2-(Diethylamino)ethyl diphenylacetate hydrochloride (1:1); Lunal; Diphenylacetyldiethylaminoethanol Hydrochloride; a-Phenylbenzeneacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2-(diethylamino)ethyl 2,2-diphenylacetate,hydrochloride; Acetic acid, diphenyl-, 2- (diethylamino)ethyl ester hydrochloride; Adiphenine Hydrochloride; 2-(Diethylamino)ethyl Diphenylacetate Hydrochloride; Adiphenine (hydrochloride) |
| Molecular Formula | C20H26O2N1Cl1 |
| Molecular Weight | 347.88 |
| Purity | 98.00 |
| Boiling Point | 423ºC at 760 mmHg |
| Melting Point | 71-74 °C(lit.) |
| Appearance | White or almost white powder |
| Storage Condition | Room temperature, sealed, dry |
| Application | Adiphenine hydrochloride is a nicotinic receptor inhibitor with antispasmodic activity. |
| EINECS | 200-036-9 |
| MDL Number | MFCD00050508 |
| SMILES | CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1.Cl |
| InChI | InChI=1S/C20H25NO2.ClH/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,19H,3-4,15-16H2,1-2H3;1H |
| InChI Key | LKPINBXAWIMZCG-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| Risk Codes | R20/21/22 |
| Safety Description | S36 |
| MSDS | msds/16553_1_50_42_0.pdf |
| Bioactivity | Adiphenine HCl is a nicotinic receptor inhibitor, used as an antispasmodic drug.Target: nAChRAdiphenine decreased the frequency of ACh-induced single-channel currents. adiphenine decreased cluster duration (36-fold at 100 micromolxL(-1)). adiphenine did not change amplitude but increased the decay rate (IC(50)= 15 micromolxL(-1)) [1]. Adiphenine was administered in3H-labelled form in doses of 15 u.mole/kg intravenously to male Wistar rats. Plasma and brain levels of the unchanged drug were measured [1]. The elimination of the3H -labelled compound from the plasma was monophasic with a half-life of 13 minutes. The unchanged drug was detectable in the plasma for 30 minutes after the injection. The time course of brain levels of unchanged drug paralleled that found in the plasma with a half-life of 9 to 12 minutes. In all experiments, brain and plasma levels of unchanged adiphenine correlate highly [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease References [1]. Spitzmaul, G., et al., The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. Br J Pharmacol, 2009. 157(5): p. 804-17. [2]. Michelot, J., et al., Adiphenine plasma levels and blood-brain barrier crossing in the rat. Eur J Drug Metab Pharmacokinet, 1985. 10(4): p. 273-8. Chemical & Physical Properties Boiling Point 423ºC at 760 mmHg Melting Point 71-74 °C(lit.) Molecular Formula C20H26ClNO2 Molecular Weight 347.879 Flash Point 133.2ºC Exact Mass 347.165222 PSA 29.54000 LogP 4.50550 InChIKey LKPINBXAWIMZCG-UHFFFAOYSA-N SMILES CCN(CC)CCOC(=O)C(c1ccccc1)c1ccccc1.Cl |
| Use of | Properties Name Adiphenine Hydrochloride Synonym More Synonyms Adiphenine Hydrochloride Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease References [1]. Spitzmaul, G., et al., The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. Br J Pharmacol, 2009. 157(5): p. 804-17. [2]. Michelot, J., et al., Adiphenine plasma levels and blood-brain barrier crossing in the rat. Eur J Drug Metab Pharmacokinet, 1985. 10(4): p. 273-8. Chemical & Physical Properties Exact Mass 347.165222 PSA 29.54000 LogP 4.50550 InChIKey LKPINBXAWIMZCG-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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