CAS Number50-24-8
SynonymsD1-Cortisol; 11b,17a,21-Trihydroxypregna-1,4-diene-3,20-dione; δ1-Dehydrocortisol; D1-Dehydrohydrocortisone; MFCD00003649; 1,4-Pregnadiene-3,20-dione-11b,17a,21-triol; Deltasolone; δ-Stab; deltaf; 1,4-Pregnadiene-11b,17a,21-triol-3,20-dione; D1-Hydrocortisone; δ-Cortef; ulacort; eazolind; Precortalon; prednis; D1-Dehydrocortisol; solone; Flamasone; Klismacort; (11β)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione; Supercortisol; 3,20-Dioxo-11b,17a,21-trihydroxy-1,4-pregnadiene; d-Cortef; Deltisolone; d-Stab; NISOLONE; STEROLONE; d-Ef-Cortelan; prednisolone
Molecular FormulaC21H28O5
Molecular Weight360.44
Purity97%
Density1.3±0.1 g/cm3
Boiling Point570.6±50.0 °C at 760 mmHg
Melting Point240 °C (dec.)(lit.)
Appearanceliquid
EINECS200-021-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50-24-8 |
| Catalog No. | 2A-9016544 |
| Chinese Name | 泼尼松龙 |
| Synonyms | D1-Cortisol; 11b,17a,21-Trihydroxypregna-1,4-diene-3,20-dione; δ1-Dehydrocortisol; D1-Dehydrohydrocortisone; MFCD00003649; 1,4-Pregnadiene-3,20-dione-11b,17a,21-triol; Deltasolone; δ-Stab; deltaf; 1,4-Pregnadiene-11b,17a,21-triol-3,20-dione; D1-Hydrocortisone; δ-Cortef; ulacort; eazolind; Precortalon; prednis; D1-Dehydrocortisol; solone; Flamasone; Klismacort; (11β)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione; Supercortisol; 3,20-Dioxo-11b,17a,21-trihydroxy-1,4-pregnadiene; d-Cortef; Deltisolone; d-Stab; NISOLONE; STEROLONE; d-Ef-Cortelan; prednisolone |
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 |
| Purity | 97 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 570.6±50.0 °C at 760 mmHg |
| Melting Point | 240 °C (dec.)(lit.) |
| Appearance | liquid |
| Storage Condition | This product is sealed and stored in a dry place a |
| Application | Prednisolone is a glucocorticoid. |
| EINECS | 200-021-7 |
| HTC | 2937229000 |
| PubChem ID | 329820079 |
| MDL Number | MFCD00003649 |
| SMILES | O[C@]1([C@@]2([C@H]([C@H]3[C@@H]([C@@]4(C(=CC(=O)C=C4)CC3)C)[C@H](C2)O)CC1)C)C(=O)CO |
| InChI | 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 |
| InChI Key | OIGNJSKKLXVSLS-VWUMJDOOSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Xn |
| Risk Codes | R22 |
| MSDS | msds/16544_1_50_24_8.pdf |
| Bioactivity | Prednisolone is a glucocorticoid with the general properties of the corticosteroids.Target: Glucocorticoid ReceptorPrednisolone is a glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Prednisolone, 5 or 50 mg/kg, was administered intravenously to adrenalectomized rats. Total plasma, free plasma, CBG-free plasma, and liver prednisolone concentrations were measured simultaneously with free hepatic cytosolic glucocorticoid receptor concentrations and tyrosine aminotransferase (TAT) activity of the liver as a function of time. prednisolone pharmacokinetics were dose-dependent, parameters describing receptor kinetics and TAT activity were constant at each prednisolone dose. The major determinants of receptor-mediated glucocorticoid activity are confirmed to be the availability of the receptor, drug-receptor dissociation rate, and corticosteroid persistence in the biophase [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Endocrinology References [1]. Boudinot, F.D., R. D'Ambrosio, and W.J. Jusko, Receptor-mediated pharmacodynamics of prednisolone in the rat. J Pharmacokinet Biopharm, 1986. 14(5): p. 469-93. [2]. Czock, D., et al., Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clinical pharmacokinetics, 2005. 44(1): p. 61-98. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 570.6±50.0 °C at 760 mmHg Melting Point 240 °C (dec.)(lit.) Molecular Formula C21H28O5 Molecular Weight 360.444 Flash Point 313.0±26.6 °C Exact Mass 360.193665 PSA 94.83000 LogP 1.50 Vapour Pressure 0.0±3.6 mmHg at 25°C Index of Refraction 1.612 InChIKey OIGNJSKKLXVSLS-VWUMJDOOSA-N SMILES CC12C=CC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)CO Storage condition -20°C Freezer |
| Use of | Properties Articles261 Name prednisolone Synonym More Synonyms prednisolone Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Endocrinology References [1]. Boudinot, F.D., R. D'Ambrosio, and W.J. Jusko, Receptor-mediated pharmacodynamics of prednisolone in the rat. J Pharmacokinet Biopharm, 1986. 14(5): p. 469-93. [2]. Czock, D., et al., Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clinical pharmacokinetics, 2005. 44(1): p. 61-98. Chemical & Physical Properties Molecular Formula C21H28O5 Exact Mass 360.193665 PSA 94.83000 Index of Refraction 1.612 InChIKey OIGNJSKKLXVSLS-VWUMJDOOSA-N |
| Transport Info | Product Name: Prednisolone |
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