CAS Number154323-57-6
Synonyms1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine; UNII-1O4XL5SN61; MFCD08063597; Almotriptan; N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine; N,N-Dimethyl-2-{5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indol-3-yl}ethanamine; N,N-Dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine; Axert; Almogran
Molecular FormulaC17H25N3O2S
Molecular Weight335.46
Purity96+%
Density1.3±0.1 g/cm3
Boiling Point538.7±60.0 °C at 760 mmHg
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 154323-57-6 |
| Catalog No. | 2A-0160249 |
| Chinese Name | 阿莫曲坦 |
| Synonyms | 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine; UNII-1O4XL5SN61; MFCD08063597; Almotriptan; N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine; N,N-Dimethyl-2-{5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indol-3-yl}ethanamine; N,N-Dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine; Axert; Almogran |
| Molecular Formula | C17H25N3O2S |
| Molecular Weight | 335.46 |
| Purity | 96+ |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 538.7±60.0 °C at 760 mmHg |
| Storage Condition | room temperature |
| Application | Almotriptan is a 5-HT1B/1D receptor agonist used to treat migraine. IC50: Target: 5-hydroxytryptamine1B/1D (5-HT1B/1D) ReceptorAlmotriptan is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor |
| EINECS | 0 |
| HTC | 2935009090 |
| UN(IATA) | 0 |
| PubChem ID | 7300482 |
| SMILES | [S](=O)(=O)(N3CCCC3)Cc1cc2c([nH]cc2CCN(C)C)cc1 |
| InChI | 1S/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3 |
| InChI Key | WKEMJKQOLOHJLZ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/160249_1_154323_57_6.pdf |
| Use of | Properties Name almotriptan Synonym More Synonyms Almotriptan Biological Activity Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor References [1]. Bou J, et al. Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. Eur J Pharmacol, 2000. 410(1): p. 33-41. [2]. Gras J, et al. Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics. Arzneimittelforschung, 2001. 51(9): p. 726-32. Chemical & Physical Properties Molecular Formula C17H25N3O2S Exact Mass 335.166748 PSA 64.79000 Index of Refraction 1.634 InChIKey WKEMJKQOLOHJLZ-UHFFFAOYSA-N Safety Information HS Code 2935009090 Precursor & DownStream Precursor 4 CAS#:334981-30-5 2-[5-(pyrrolidi... CAS#:50-00-0 Formaldehyde CAS#:181178-24-5 Didesmethyl Alm... CAS#:1112206-16-2 N,N-dimethyl-4-... DownStream 1 CAS#:181183-52-8 Almotriptan |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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