![INDOLO[3,2-B]CARBAZOLE-6-CARBALDEHYDE structure, CAS 172922-91-7](/structures/180000/156332_1_172922_91_7.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 172922-91-7 |
| Catalog No. | 2A-0156332 |
| Chinese Name | 6-甲酰基吲哚并(3 |
| Synonyms | Indolo[3,2-b]carbazole-6-carboxaldehyde; Indolo[3,2-b]carbazole-6-carbaldehyde; 6-formylindolo(3,2-b)carbazole; FICZ |
| Molecular Formula | C19H12N2O |
| Molecular Weight | 284.31 |
| Purity | 96+ |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 463.8±45.0 °C at 760 mmHg |
| Storage Condition | 2-8°C |
| Application | FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd value of 70 pM. |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| PubChem ID | 6755093 |
| SMILES | O=Cc1c2[nH]c3ccccc3c2cc2[nH]c3ccccc3c12 |
| InChI | InChI=1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H |
| InChI Key | ZUDXFBWDXVNRKF-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Use of | FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM. Properties Name 6-formylindolo a carbazole Synonym More Synonyms FICZ Biological Activity Description FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Others Cell Assay The cell viability of CEH treated with FICZ or TCDD is studied with the untreated cells (used as a live cell control) and sodium hypochlorite (5%)-treated cells (used as a dead cell control). This assay is based upon the bioluminescent measurement of adenosine triphosphate (ATP) that is present in all metabolically active cells. Luciferase is utilized in this method to catalyze the formation of light from ATP and luciferin. CEH are lysed 24 h after dosing and the luminescence emitted from the ATP-dependent oxidation of luciferin is measured with a LuminoSkan Ascent luminometer. References [1]. Mohammadi-Bardbori A, et al. The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro. Arch Toxicol. 2017 Mar 13 [2]. Farmahin R, et al. Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation time. Biochem Pharmacol. 2016 Sep 1;115:134-43 [4]. Wincent E, et al. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol. 2016 Jun 15;110-111:117-29. Chemical & Physical Properties Molecular Formula C19H12N2O PSA 41.79000 Index of Refraction 1.772 InChIKey ZUDXFBWDXVNRKF-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Heterocyclic Building Blocks | ||
|---|---|---|
| IMIDAZO[5,1-B]THIAZOLE-7-CARBOXYLIC ACID | 211033-78-2 | 2A-0156281 |
| IMIDAZO[5,1-F][1,2,4]TRIAZIN-4(3H)-ONE | 865444-76-4 | 2A-0156282 |
| INDOLINE-4-CARBOXYLIC ACID | 175647-03-7 | 2A-0156322 |
| INDOLINE-7-CARBALDEHYDE | 143262-21-9 | 2A-0156326 |
| INDOLO[2,1-B]QUINAZOLINE-6,12-DIONE | 13220-57-0 | 2A-0156330 |
| ISOBUTYL 4-(4-BROMOPHENYL)PIPERAZINE-1-CARBOXYLATE | 1226808-71-4 | 2A-0156348 |
| ISOCHROMAN-4-AMINE HYDROCHLORIDE | 1159599-95-7 | 2A-0156356 |
| ISOCHROMAN-4-OL | 20924-57-6 | 2A-0156357 |
| ISOCHROMAN-6-AMINE | 444588-39-0 | 2A-0156359 |
| ISOINDOLINE-5-CARBOXYLIC ACID HYDROCHLORIDE | 149353-72-0 | 2A-0156366 |
| Browse all Heterocyclic Building Blocks products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS