![INDOLO[2,1-B]QUINAZOLINE-6,12-DIONE structure, CAS 13220-57-0](/structures/180000/156330_1_13220_57_0.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 13220-57-0 |
| Catalog No. | 2A-0156330 |
| Chinese Name | 吲哚并[2,1-b]喹唑啉-6,12-二酮 |
| Synonyms | Tryptanthrin; MFCD00012073; indolo[2,1-b]quinazoline-6,12-dione |
| Molecular Formula | C15H8N2O2 |
| Molecular Weight | 248.24 |
| Purity | 96+ |
| Density | 1.45g/cm3 |
| Boiling Point | 469.3ºC at 760 mmHg |
| Storage Condition | room temperature |
| Application | Tryptanthrin is a potent orally active intracellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin inhibits Leukotriene formation in human whole blood (IC50 = 10 µM) and reduces LTB4 levels in |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| PubChem ID | 12925 |
| MDL Number | MFCD00012073 |
| SMILES | O=C1c2ccccc2-n2c1nc1ccccc1c2=O |
| InChI | InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H |
| InChI Key | VQQVWGVXDIPORV-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Use of | Properties Articles31 Name Couroupitine A Indolo(2,1-b)quinazoline-6,12-dione Tryptanthrine Synonym More Synonyms Tryptanthrine Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology IC50: 10 µM (LT formation in human whole blood)[1] References [1]. Pergola C, et al. On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo.Br J Pharmacol. 2012 Feb;165(3):765-76. Chemical & Physical Properties Molecular Formula C15H8N2O2 Exact Mass 248.05900 PSA 51.96000 LogP 1.93010 Index of Refraction 1.762 InChIKey VQQVWGVXDIPORV-UHFFFAOYSA-N Safety Information RIDADR NONH for all modes of transport HS Code 2933990090 Synthetic Route Isatoic anhydri... Tryptanthrine 13220-57-0 Literature: Tetrahedron, , vol. 41, # 14 p. 2879 - 2882 13220-56-9 Tryptanthrine 13220-57-0 Literature: Journal of Organic Chemistry, , vol. 58, # 2 p. 310 - 312 Tryptanthrine 13220-57-0 Literature: Russian Journal of Organic Chemistry, , vol. 33, # 1 p. 125 - 126 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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