CAS Number6404-29-1
Synonyms6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)hexanoic acid; 6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid; 6-[(tert-butoxycarbonyl)amino]hexanoic acid; MFCD00037798; Boc-ε-Acp-OH; Boc-ε-Ahx-OH
Molecular Formula(CH3)3CO2CNH(CH2)5CO2H
Molecular Weight231.29
Purity96+%
Density1.1±0.1 g/cm3
Boiling Point380.3±25.0 °C at 760 mmHg
Melting Point35-40 °C
AppearanceSolid;White to Light yellow powder to lump
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6404-29-1 |
| Catalog No. | 2A-0151440 |
| Chinese Name | Boc-6-氨基己酸 |
| Synonyms | 6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)hexanoic acid; 6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid; 6-[(tert-butoxycarbonyl)amino]hexanoic acid; MFCD00037798; Boc-ε-Acp-OH; Boc-ε-Ahx-OH |
| Molecular Formula | (CH3)3CO2CNH(CH2)5CO2H |
| Molecular Weight | 231.29 |
| Purity | 96+ |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 380.3±25.0 °C at 760 mmHg |
| Melting Point | 35-40 °C |
| Appearance | Solid;White to Light yellow powder to lump |
| Storage Condition | 2-8°C, sealed, stored in a cool and dry place, ens |
| Application | Boc-6-aminohexanoic acid is a PROTAC linker, belonging to the alkyl/ether class. Can be used to synthesize PROTAC molecules. |
| EINECS | 0 |
| HTC | 2924199090 |
| UN(IATA) | 0 |
| PubChem ID | 57647407 |
| MDL Number | MFCD00037798 |
| SMILES | CC(C)(C)OC(=O)NCCCCCC(=O)O |
| InChI | InChI=1S/C11H21NO4/c1-11(2,3)16-10(15)12-8-6-4-5-7-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14) |
| InChI Key | RUFDYIJGNPVTAY-UHFFFAOYSA-N |
| Beilstein/REAXYS | 2049561 |
| NACRES Code | NA.22 |
| UNSPSC | 12352209 |
| Hazard Symbols | transportation |
| Bioactivity | Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 380.3±25.0 °C at 760 mmHg Melting Point 35-40 °C Molecular Formula C11H21NO4 Molecular Weight 231.289 Flash Point 183.8±23.2 °C Exact Mass 231.147064 PSA 75.63000 LogP 1.67 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.464 InChIKey RUFDYIJGNPVTAY-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCCCCC(=O)O Storage condition 2-8°C |
| Use of | Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name Boc-6-aminohexanoic acid Synonym More Synonyms Boc-6-aminohexanoic acid Biological Activity Description Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C11H21NO4 Exact Mass 231.147064 PSA 75.63000 Index of Refraction 1.464 InChIKey RUFDYIJGNPVTAY-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCCCCC(=O)O |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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