CAS Number142929-49-5
Synonyms{2-[(tert-Butoxycarbonyl)amino]ethoxy}acetic acid; [2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)ethoxy]acetic acid; AmbotzBAA5240
Molecular FormulaC9H17NO5
Molecular Weight219.235
Purity96+%
Density1.2±0.1 g/cm3
Boiling Point391.2±22.0 °C at 760 mmHg
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 142929-49-5 |
| Catalog No. | 2A-0151438 |
| Chinese Name | Boc-5-氨基-3-氧杂戊酸 |
| Synonyms | {2-[(tert-Butoxycarbonyl)amino]ethoxy}acetic acid; [2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)ethoxy]acetic acid; AmbotzBAA5240 |
| Molecular Formula | C9H17NO5 |
| Molecular Weight | 219.235 |
| Purity | 96+ |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 391.2±22.0 °C at 760 mmHg |
| Storage Condition | -20°C, dry and sealed |
| Application | Boc-NH-PEG1-CH2COOH is a PROTAC linker, belonging to the PEG class. Can be used to synthesize PROTAC molecules. |
| EINECS | 0 |
| HTC | 2924199090 |
| UN(IATA) | 0 |
| PubChem ID | 46400246 |
| SMILES | CC(C)(C)OC(=O)NCCOCC(=O)O |
| InChI | InChI=1S/C9H17NO5/c1-9(2,3)15-8(13)10-4-5-14-6-7(11)12/h4-6H2,1-3H3,(H,10,13)(H,11,12) |
| InChI Key | UPBQMAHYLWJGDW-UHFFFAOYSA-N |
| Use of | Properties Name 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]acetic acid Synonym More Synonyms Boc-O1Pen-OH * DCHA Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C9H17NO5 Exact Mass 219.110672 PSA 84.86000 Index of Refraction 1.462 InChIKey UPBQMAHYLWJGDW-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCOCC(=O)O Safety Information HS Code 2924199090 Synthetic Route Boc-NH-PEG1-OH CAS#:26690-80-2 Chloroacetic acid CAS#:79-11-8 Boc-O1Pen-OH * DCHA CAS#:142929-49-5 4-MORPHOLINECAR... CAS#:142929-48-4 Boc-O1Pen-OH * DCHA CAS#:142929-49-5 Literature: Chandrakumar; Stapelfeld; Beardsley; Lopez; Drury; Anthony; Savage; Williamson; Reichman Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2928 - 2938 CAS#:142929-50-8 Boc-O1Pen-OH * DCHA CAS#:142929-49-5 Literature: Adamczyk, Maciej; Fishpaugh, Jeffrey R.; Thiruvazhi, Mohan Organic Preparations and Procedures International, 2002 , vol. 34, # 3 p. 326 - 331 Precursor & DownStream Precursor 3 CAS#:26690-80-2 Boc-NH-PEG1-OH CAS#:79-11-8 Chloroacetic acid CAS#:24424-99-5 Di-tert-butyl d... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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