| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61563-24-4 |
| Catalog No. | 2A-0148906 |
| Chinese Name | 7,8-二氯-1,2,3,4-四氢异喹啉 |
| Synonyms | 7,8-Dichlor-1,2,3,4-tetrahydroisochinolin; 1yz3; 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline; SK&SKA |
| Molecular Formula | C9H9Cl2N |
| Molecular Weight | 202.08000 |
| Purity | 96+ |
| Density | 1.293g/cm3 |
| Boiling Point | 310.7ºC at 760 mmHg |
| Application | 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11) is a tetrahydroisoquinine (THIQ) derivative and a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. |
| EINECS | 0 |
| HTC | 2933499090 |
| UN(IATA) | 0 |
| SMILES | Clc1ccc2c(c1Cl)CNCC2 |
| InChI | InChI=1S/C9H9Cl2N/c10-8-2-1-6-3-4-12-5-7(6)9(8)11/h1-2,12H,3-5H2 |
| InChI Key | WFPUBEDBBOGGIQ-UHFFFAOYSA-N |
| Use of | 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1]. Properties Name 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline Synonym More Synonyms Biological Activity Description 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1]. Related Catalog Research Areas >> Neurological Disease References [1]. Pramod C Nair, et al. Using Theory to Reconcile Experiment: The Structural and Thermodynamic Basis of Ligand Recognition by Phenylethanolamine N-Methyltransferase (PNMT). J Chem Theory Comput. 2011 May 10;7(5):1458-68. Chemical & Physical Properties Exact Mass 201.01100 PSA 12.03000 LogP 2.96790 Index of Refraction 1.574 InChIKey WFPUBEDBBOGGIQ-UHFFFAOYSA-N Safety Information HS Code 2933499090 Synthetic Route Total: 1 Page 7,8-Dichloroiso... CAS#:61563-36-8 Isoquinoline, 7... CAS#:61563-24-4 Literature: Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511 2,3-Dichloroben... CAS#:6334-18-5 Isoquinoline, 7... CAS#:61563-24-4 Literature: Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511 1-(2,3-dichloro... CAS#:57987-75-4 Isoquinoline, 7... CAS#:61563-24-4 Literature: Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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