![4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)PHENOL structure, CAS 496864-16-5](/structures/150000/135491_1_496864_16_5.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 496864-16-5 |
| Catalog No. | 2A-0135491 |
| Chinese Name | 7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪 |
| Synonyms | 1ung; RP107; Aloisine A RP107; ALOISINE A; ALH; 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol |
| Molecular Formula | C16H17N3O |
| Molecular Weight | 267.33 |
| Purity | ≥95 (HPLC) |
| Density | 1.227g/cm3 |
| Melting Point | 281-283ºC |
| Appearance | solid |
| Application | Aloe base A (RP107) is a potent cyclin-dependent kinase (CDK) inhibitor, with IC50s of 0.15 μM, 0.12 μM, 0.4 μM, and 0.16 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, and CDK5/p35, respectively |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| MDL Number | MFCD04973541 |
| SMILES | [nH]1c2nccnc2c(c1c3ccc(cc3)O)CCCC |
| InChI | 1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19) |
| InChI Key | PRIGRJPRGZCFAS-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/135491_1_496864_16_5.pdf |
| Use of | Properties Name 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-1-one Synonym More Synonyms Aloisine A Biological Activity Related Catalog Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3 Signaling Pathways >> Stem Cell/Wnt >> ERK GSK-3β:0.5 μM (IC50) GSK-3α:1.5 μM (IC50) JNK:3-10 μM (IC50) ERK1:18 μM (IC50) ERK2:22 μM (IC50) References [2]. Sabrina Noel, et al. Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels. J Pharmacol Exp Ther. 2006 Oct;319(1):349-59. Chemical & Physical Properties Molecular Formula C16H17N3O Exact Mass 267.13700 PSA 61.80000 LogP 3.67310 Index of Refraction 1.655 InChIKey PRIGRJPRGZCFAS-UHFFFAOYSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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