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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE
4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE structure, CAS 102676-47-1

4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE

CAS Number102676-47-1

SynonymsFadrozole; 5-p-cyanophenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine; 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile; Afema; 4-(5,6,7,8-Tetrahydroimidazo1,5-apyridin-5-yl)benzonitrile; 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonitrile

Molecular FormulaC14H13N3

Molecular Weight223.28

Purity96+%

Density1.2±0.1 g/cm3

Boiling Point481.7±38.0 °C at 760 mmHg

Melting Point0ºC

Flash Point

Appearance

EINECS0

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Cat. No.: 2A-0135385 Purity: 96+%
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Quality Control of [ 102676-47-1 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number102676-47-1
Catalog No.2A-0135385
Chinese Name法倔唑
SynonymsFadrozole; 5-p-cyanophenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine; 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile; Afema; 4-(5,6,7,8-Tetrahydroimidazo1,5-apyridin-5-yl)benzonitrile; 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonitrile
Molecular FormulaC14H13N3
Molecular Weight223.28
Purity96+
Density1.2±0.1 g/cm3
Boiling Point481.7±38.0 °C at 760 mmHg
Melting Point0ºC
Storage Condition2-8℃
ApplicationFadrozole is a potent, selective and non-steroidal aromatase inhibitor with an IC50 value of 6.4 nM.
EINECS0
HTC2933990090
UN(IATA)0
MDL NumberMFCD02313480
SMILESN#Cc1ccc(C2CCCc3cncn32)cc1
InChIInChI=1S/C14H13N3.ClH/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14;/h4-7,9-10,14H,1-3H2;1H
InChI KeyCLPFFLWZZBQMAO-UHFFFAOYSA-N
MSDSmsds/135385_1_102676_47_1.pdf
Use ofFadrozole is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. Properties Name 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Synonym More Synonyms Fadrozole Biological Activity Description Fadrozole is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. Related Catalog Signaling Pathways >> Others >> Aromatase Research Areas >> Cancer IC50: 6.4 nM (aromatase)[1] In Vitro Fadrozole hydrochloride is a very potent inhibitor of both human placental and rat ovarian aromatase. In hamster ovarian slices, fadrozole hydrochloride inhibits the production of estrogen with an IC50 of 0.03 μM. The production of progesterone is inhibited with an IC50 of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of fadrozole hydrochloride. [1]. References [1]. Browne LJ, et al. Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34(2):725-36. [2]. Gunson DE, et al. Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. Br J Cancer. 1995 Jul;72(1):72-5. [3]. Morales-Montor J, et al. Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis. Int J Parasitol. 2002 Oct;32(11):1379-87. Chemical & Physical Properties Molecular Formula C14H13N3 Exact Mass 223.110947 PSA 41.61000 Index of Refraction 1.662 InChIKey CLPFFLWZZBQMAO-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information RIDADR UN 3439 HS Code 2933990090 Synthetic Route 5-(4-carbamylph... 102676-43-7 102676-47-1 Literature: Browne, L. J.; Gude, C.; Rodriguez, H.; Steele, R. E. Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 725 - 736 ethyl 4-pyridin... 102676-47-1 Literature: Journal of Medicinal Chemistry, , vol. 34, # 2 p. 725 - 736 102676-38-0 102676-47-1 Literature: Journal of Medicinal Chemistry, , vol. 34, # 2 p. 725 - 736 Precursor & DownStream Precursor 3 CAS#:4385-61-9 ethyl 4-pyridin... CAS#:102676-39-1 6-cyano-2-[4-(e... CAS#:93178-73-5 4-(5,6,7,8-tetr... DownStream 0
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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