CAS Number93-07-2
SynonymsMFCD00002500; EINECS 202-215-7; 3,4-Dimethoxybenzoic acid; Veratric acid
Molecular Formula(CH3O)2C6H3CO2H
Molecular Weight182.17
Purity≥99%
Density1.2±0.1 g/cm3
Boiling Point302.9±22.0 °C at 760 mmHg
Melting Point179-182 °C (lit.)
Appearancepowder
EINECS202-215-7
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 93-07-2 |
| Catalog No. | 2A-9013388 |
| Chinese Name | 藜芦酸 |
| Synonyms | MFCD00002500; EINECS 202-215-7; 3,4-Dimethoxybenzoic acid; Veratric acid |
| Molecular Formula | (CH3O)2C6H3CO2H |
| Molecular Weight | 182.17 |
| Purity | ≥99 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 302.9±22.0 °C at 760 mmHg |
| Melting Point | 179-182 °C (lit.) |
| Appearance | powder |
| Water Solubility | slightly soluble |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Veratric acid (3,4-Dimethoxybenzoic acid) is a polyphenolic substance obtained from vegetables and fruits. It can be taken orally and has antioxidant [1], cardiovascular protection [2] and anti-inflam |
| EINECS | 202-215-7 |
| HTC | 2918990090 |
| PubChem ID | 24893253 |
| MDL Number | MFCD00002500 |
| SMILES | COc1ccc(cc1OC)C(O)=O |
| InChI | 1S/C9H10O4/c1-12-7-4-3-6(9(10)11)5-8(7)13-2/h3-5H,1-2H3,(H,10,11) |
| InChI Key | DAUAQNGYDSHRET-UHFFFAOYSA-N |
| Beilstein/REAXYS | 518285 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/13388_1_93_07_2.pdf |
| Bioactivity | Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3]. Related Catalog Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology Research Areas >> Cardiovascular Disease Target COX-2[3] In Vitro Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation and HDAC3 expression in RAW264.7 cells[1]. Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis[3]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3]. In Vivo Veratric acid (40 mg/kg, p.o., b.w.) significantly promotes ventricular function, reduces lipid peroxidation and increases antioxidants in l-NAME-induced hypertensive rats[2]. References [1]. Choi WS, et al. Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells. Int J Mol Med. 2015 Jan;35(1):202-10. [2]. Saravanakumar M, et al. Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation. Br J Nutr. 2015 Nov 14;114(9):1385-94. [3]. Shin SW, et al. Antagonist effects of veratric acid against UVB-induced cell damages. Molecules. 2013 May 10;18(5):5405-19. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 302.9±22.0 °C at 760 mmHg Melting Point 179-182 °C(lit.) Molecular Formula C9H10O4 Molecular Weight 182.173 Flash Point 120.9±15.8 °C Exact Mass 182.057907 PSA 55.76000 LogP 1.99 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.533 InChIKey DAUAQNGYDSHRET-UHFFFAOYSA-N SMILES COc1ccc(C(=O)O)cc1OC Storage condition Refrigerator Stability Stable. Incompatible with strong oxidizing agents. Water Solubility slightly soluble |
| Use of | Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3]. Properties Articles28 Name 3,4-dimethoxybenzoic acid Synonym More Synonyms Veratric acid Biological Activity Description Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3]. Related Catalog Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology Research Areas >> Cardiovascular Disease References [2]. Saravanakumar M, et al. Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation. Br J Nutr. 2015 Nov 14;114(9):1385-94. [3]. Shin SW, et al. Antagonist effects of veratric acid against UVB-induced cell damages. Molecules. 2013 May 10;18(5):5405-19. Chemical & Physical Properties Molecular Formula C9H10O4 Exact Mass 182.057907 PSA 55.76000 Index of Refraction 1.533 InChIKey DAUAQNGYDSHRET-UHFFFAOYSA-N Storage condition Refrigerator Stability Stable. Incompatible with strong oxidizing agents. Water Solubility slightly soluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards 3,4-Dimethoxybenzoic acid Modification number: 6 Module 14. Shipping information UN number: not specified |
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