CAS Number3943-89-3
Synonyms3,4-dihydroxybenzoic acid ethyl ether; Ethyl-3,4-dihydroxybenzoate; Benzoic acid, 3,4-dihydroxy-, ethyl ester; Ethyl protocatechuate; EDHB; 3,4-Dihydroxybenzoic acid ethyl ester; EINECS 223-529-0; Protocatechuic acid ethyl ester; MFCD00002199; Ethyl 3,4-dihydroxybenzoate
Molecular Formula(HO)2C6H3CO2C2H5
Molecular Weight182.17
Purity97%
Density1.3±0.1 g/cm3
Boiling Point358.1±22.0 °C at 760 mmHg
Melting Point132-134 °C (lit.)
Appearancewhite crystal or powder
EINECS223-529-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3943-89-3 |
| Catalog No. | 2A-9013385 |
| Chinese Name | 3,4-二羟基苯甲酸乙酯 |
| Synonyms | 3,4-dihydroxybenzoic acid ethyl ether; Ethyl-3,4-dihydroxybenzoate; Benzoic acid, 3,4-dihydroxy-, ethyl ester; Ethyl protocatechuate; EDHB; 3,4-Dihydroxybenzoic acid ethyl ester; EINECS 223-529-0; Protocatechuic acid ethyl ester; MFCD00002199; Ethyl 3,4-dihydroxybenzoate |
| Molecular Formula | (HO)2C6H3CO2C2H5 |
| Molecular Weight | 182.17 |
| Purity | 97 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 358.1±22.0 °C at 760 mmHg |
| Melting Point | 132-134 °C (lit.) |
| Appearance | white crystal or powder |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Store at room temperature, away from light, in a v |
| Application | Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate) is an antioxidant and inhibitor of prolyl-hydroxylase found in the seed coat of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by act |
| EINECS | 223-529-0 |
| HTC | 2918290000 |
| PubChem ID | 24894472 |
| MDL Number | MFCD00002199 |
| SMILES | CCOC(=O)c1ccc(O)c(O)c1 |
| InChI | 1S/C9H10O4/c1-2-13-9(12)6-3-4-7(10)8(11)5-6/h3-5,10-11H,2H2,1H3 |
| InChI Key | KBPUBCVJHFXPOC-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| MSDS | msds/13385_1_3943_89_3.pdf |
| Bioactivity | Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and apoptosis in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect[1][2][3][4]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Metabolic Disease References [1]. Bo Han, et al. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS One. 2014 Sep 18;9(9):e107204. [2]. Sebastian Philipp, et al. Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H450-7. [3]. Byeong-Ju Kwon, et al. Ethyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering. Tissue Eng Part A. 2014 Nov;20(21-22):2975-84. [4]. D Nandan, et al. Ethyl-3,4-dihydroxybenzoate inhibits myoblast differentiation: evidence for an essential role of collagen. J Cell Biol. 1990 May;110(5):1673-9. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 358.1±22.0 °C at 760 mmHg Melting Point 132-134 °C(lit.) Molecular Formula C9H10O4 Molecular Weight 182.173 Flash Point 147.0±15.8 °C Exact Mass 182.057907 PSA 66.76000 LogP 2.22 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.574 InChIKey KBPUBCVJHFXPOC-UHFFFAOYSA-N SMILES CCOC(=O)c1ccc(O)c(O)c1 |
| Use of | Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and apoptosis in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect[1][2][3][4]. Properties Articles30 Name Ethyl 3,4-dihydroxybenzoate Synonym More Synonyms Ethyl 3,4-dihydroxybenzoate Biological Activity Description Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and apoptosis in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect[1][2][3][4]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Metabolic Disease References [1]. Bo Han, et al. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS One. 2014 Sep 18;9(9):e107204. [2]. Sebastian Philipp, et al. Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H450-7. [3]. Byeong-Ju Kwon, et al. Ethyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering. Tissue Eng Part A. 2014 Nov;20(21-22):2975-84. [4]. D Nandan, et al. Ethyl-3,4-dihydroxybenzoate inhibits myoblast differentiation: evidence for an essential role of collagen. J Cell Biol. 1990 May;110(5):1673-9. Chemical & Physical Properties Molecular Formula C9H10O4 Exact Mass 182.057907 PSA 66.76000 Index of Refraction 1.574 InChIKey KBPUBCVJHFXPOC-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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