CAS Number125317-39-7
SynonymsMFCD03613607; Vinorelbine Ditartarate; Nor-5'-anhydrovinblastine ditartrate; Vinorelbine ditartrate salt; Eunades; Vinorelbine tartrate; 6-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate bis(2,3-dihydroxybutanedioate) (salt); ethyl ester, (2β,3β,4β,5α,12β,19α)-, 2,3-dihydroxybutanedioate (1:2) (salt); 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2) (salt); Vinorelbine ditartrate; Vinorelbine; Vinorelbine (ditartrate)
Molecular FormulaC53H66N4O20
Molecular Weight1079.106
Purity98%
Density1.36g/cm3
Melting Point181-183°C
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 125317-39-7 |
| Catalog No. | 2A-9012937 |
| Chinese Name | 酒石酸长春瑞滨 |
| Synonyms | MFCD03613607; Vinorelbine Ditartarate; Nor-5'-anhydrovinblastine ditartrate; Vinorelbine ditartrate salt; Eunades; Vinorelbine tartrate; 6-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate bis(2,3-dihydroxybutanedioate) (salt); ethyl ester, (2β,3β,4β,5α,12β,19α)-, 2,3-dihydroxybutanedioate (1:2) (salt); 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2) (salt); Vinorelbine ditartrate; Vinorelbine; Vinorelbine (ditartrate) |
| Molecular Formula | C53H66N4O20 |
| Molecular Weight | 1079.106 |
| Purity | 98 |
| Density | 1.36g/cm3 |
| Melting Point | 181-183°C |
| Appearance | White to off-white crystalline powder |
| Water Solubility | H2O: 10 mg/mL |
| Storage Condition | Sealed, stored at 2ºC -8ºC |
| Application | Vinorelbine ditartrate is an antimitotic agent that inhibits the proliferation of HeLa cells with an IC50 value of 1.25 nM. |
| HTC | 2942000000 |
| SMILES | CCC1=CC2CN(C1)Cc1c([nH]c3ccccc13)C(C(=O)OC)(c1cc3c(cc1OC)N(C)C1C(O)(C(=O)OC)C(OC(C)=O)C4(CC)C=CCN5CCC31C54)C2.O=C(O)C(O)C(O)C(=O)O.O=C(O)C(O)C(O)C(=O)O |
| InChI | InChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28?,37-,38+,39+,42+,43+,44-,45-;2*1-,2-/m011/s1 |
| InChI Key | CILBMBUYJCWATM-KRQCOKQWSA-N |
| MSDS | msds/12937_1_125317_39_7.pdf |
| Use of | Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. Properties Name vinorelbine L-tartrate Synonym More Synonyms Vinorelbine (ditartrate) Biological Activity Description Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Cancer In Vitro Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase[1]. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner[2]. References [1]. Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32. [3]. Poirier VJ, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug;18(4):536-9. [4]. Pierro JA, et al. Phase I clinical trial of vinorelbine in tumor-bearing cats. J Vet Intern Med. 2013 Jul-Aug;27(4):943-8. Chemical & Physical Properties Molecular Formula C53H66N4O20 Exact Mass 1078.427002 PSA 363.99000 LogP 0.44920 Index of Refraction 1.675 InChIKey CILBMBUYJCWATM-KRQCOKQWSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CAS REGISTRY NUMBER : 125317-39-7 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 7-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 27,1375,1993 Safety Information Hazard Codes Xi:Irritant Risk Phrases R43 Safety Phrases 26-36 RIDADR NONH for all modes of transport WGK Germany 3 HS Code 2942000000 |
| Transport Info | Product name: Vinorelbine tartrate |
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