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Valinomycin structure, CAS 2001-95-8

Valinomycin

CAS Number2001-95-8

SynonymsValinomycin; antibioticn-329b; valinomicin; EINECS 217-896-6; BU 226 hydrochloride; MFCD00005114

Molecular FormulaC54H90N6O18

Molecular Weight1111.322

Purity98.00%

Density1.1±0.1 g/cm3

Boiling Point1333.9±65.0 °C at 760 mmHg

Melting Point186-190ºC

Flash Point

Appearancewhite solid

EINECS

MSDSChineseEnglish

Symbol6.1(a)

Signal WordWarning

Cat. No.: 2A-9012907 Purity: 98.00%
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Quality Control of [ 2001-95-8 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number2001-95-8
Catalog No.2A-9012907
Chinese Name缬氨霉素
SynonymsValinomycin; antibioticn-329b; valinomicin; EINECS 217-896-6; BU 226 hydrochloride; MFCD00005114
Molecular FormulaC54H90N6O18
Molecular Weight1111.322
Purity98.00
Density1.1±0.1 g/cm3
Boiling Point1333.9±65.0 °C at 760 mmHg
Melting Point186-190ºC
Appearancewhite solid
Storage ConditionSealed, stored at 2ºC -8ºC
ApplicationValinomycin (NSC 122023) is a cyclic depsipeptide antibiotic originally isolated from Streptomyces fulvissimus and is a potassium ion selective transport carrier. Valinomycin (NSC 122023) inhibits the
SMILESCC1OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC1=O
InChIInChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36?,37-,38-,39-,40+,41+,42+/m0/s1
InChI KeyFCFNRCROJUBPLU-ZJUJSLGGSA-N
Hazard Symbols6.1(a)
BioactivityValinomycin (NSC 122023) is a cyclic depsipeptide antibiotic first isolated from Streptomyces fulvissimus, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Daniele RP, et al. A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3599-602. [2]. Tosteson DC, et al. The effect of valinomycin on potassium and sodium permeability of HK and LK sheep red cells. J Gen Physiol. 1967 Dec;50(11):2513-25. [3]. Abdalah R, et al. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett. 2006 Sep 11;405(1-2):68-73. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 1333.9±65.0 °C at 760 mmHg Melting Point 186-190ºC Molecular Formula C54H90N6O18 Molecular Weight 1111.322 Flash Point 760.5±34.3 °C Exact Mass 1110.631104 PSA 332.40000 LogP -2.08 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.449 InChIKey FCFNRCROJUBPLU-ZJUJSLGGSA-N SMILES CC1OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC1=O Storage condition 2~8°C
Use ofValinomycin (NSC 122023) is a cyclic depsipeptide antibiotic first isolated from Streptomyces fulvissimus, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells[1]. Properties Articles72 Name valinomycin Synonym More Synonyms Valinomycin Biological Activity Description Valinomycin (NSC 122023) is a cyclic depsipeptide antibiotic first isolated from Streptomyces fulvissimus, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Daniele RP, et al. A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3599-602. [2]. Tosteson DC, et al. The effect of valinomycin on potassium and sodium permeability of HK and LK sheep red cells. J Gen Physiol. 1967 Dec;50(11):2513-25. [3]. Abdalah R, et al. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett. 2006 Sep 11;405(1-2):68-73. Chemical & Physical Properties Molecular Formula C54H90N6O18 Exact Mass 1110.631104 PSA 332.40000 LogP -2.08 Index of Refraction 1.449 InChIKey FCFNRCROJUBPLU-ZJUJSLGGSA-N SMILES CC1OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC1=O
Transport InfoProduct name: Valinomycin
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