CAS Number1775-97-9
Synonyms(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one; CARDAMONIN-4'-METHYL ETHER; 2'-Hydroxy-4',6'-dimethoxychalcone; flavokawin B; (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one; (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one; 1OR CQ EO1 BV1U1R &&E Form; MFCD00075877; DIMETHOXY-2'-HYDROXYCHALCONE,4',6'; Flavokawain B; Flavokavain B
Molecular FormulaC17H16O4
Molecular Weight284.31
Purity≥98.0 (HPLC)%
Density1.203±0.06 g/cm3
Boiling Point500.1±50.0 °C at 760 mmHg
Melting Point178-179 ºC (ethanol )
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1775-97-9 |
| Catalog No. | 2A-9000129 |
| Chinese Name | 黄卡瓦胡椒素B |
| Synonyms | (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one; CARDAMONIN-4'-METHYL ETHER; 2'-Hydroxy-4',6'-dimethoxychalcone; flavokawin B; (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one; (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one; 1OR CQ EO1 BV1U1R &&E Form; MFCD00075877; DIMETHOXY-2'-HYDROXYCHALCONE,4',6'; Flavokawain B; Flavokavain B |
| Molecular Formula | C17H16O4 |
| Molecular Weight | 284.31 |
| Purity | ≥98.0 (HPLC) |
| Density | 1.203±0.06 g/cm3 |
| Boiling Point | 500.1±50.0 °C at 760 mmHg |
| Melting Point | 178-179 ºC (ethanol ) |
| Appearance | powder |
| Water Solubility | Practically insoluble (0.012 g/L) (25 ºC) |
| Storage Condition | -20℃ |
| Application | Flavokawain B (Flavokavain B), a chalcone isolated from the root extract of kava zanthoxylum, is an effective inducer of apoptosis that inhibits the growth of various cancer cell lines. (Flavokavain B |
| HTC | 2914509090 |
| MDL Number | MFCD00075877 |
| SMILES | O(C)c1c(c(cc(c1)OC)O)C(=O)\C=C\c2ccccc2 |
| InChI | 1S/C17H16O4/c1-20-13-10-15(19)17(16(11-13)21-2)14(18)9-8-12-6-4-3-5-7-12/h3-11,19H,1-2H3/b9-8+ |
| InChI Key | QKQLSQLKXBHUSO-CMDGGOBGSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/129_1_1775_97_9.pdf |
| Use of | Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2]. Properties Name 4',6'-dimethoxy-2'-hydroxychalcone Synonym More Synonyms Flavokawain B Biological Activity Description Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [1]. Rossette MC, et al. The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B. Phytother Res. 2017 Oct;31(10):1607-1613. [2]. Li X, et al. Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation. Cell Commun Signal. 2019 Mar 18;17(1):25. Chemical & Physical Properties Molecular Formula C17H16O4 Exact Mass 284.104858 PSA 55.76000 Index of Refraction 1.614 InChIKey QKQLSQLKXBHUSO-CMDGGOBGSA-N Storage condition -20℃ Safety Information HS Code 2914509090 Synthetic Route Total: 1 Page Xanthoxylin CAS#:90-24-4 Benzaldehyde CAS#:100-52-7 Flavokawain B CAS#:1775-97-9 Literature: Singh, Om V.; Muthukrishnan; Sunderavadivelu Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 12 p. 2575 - 2581 5,7-Dimethoxyfl... CAS#:1036-72-2 Flavokawain B CAS#:1775-97-9 Literature: Pouget, Christelle; Lauthier, Fabienne; Simon, Alain; Fagnere, Catherine; Basly, Jean-Philippe; Delage, Christiane; Chulia, Albert-Jose Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3095 - 3097 2',4',6'-Trihyd... CAS#:480-66-0 Flavokawain B CAS#:1775-97-9 Literature: Seo, Young Ho; Park, Sun You Bulletin of the Korean Chemical Society, 2014 , vol. 35, # 4 p. 1154 - 1158 Precursor & DownStream Precursor 4 CAS#:90-24-4 Xanthoxylin CAS#:100-52-7 Benzaldehyde CAS#:1036-72-2 5,7-Dimethoxyfl... CAS#:480-66-0 2',4',6'-Trihyd... DownStream 9 CAS#:26964-35-2 5,7-DIMETHOXYIS... CAS#:3187-19-7 Benzoic acid,2-... CAS#:93-58-3 Methyl benzoate CAS#:100-52-7 Benzaldehyde |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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