CAS Number34140-59-5
SynonymsUNII:2A051GM4YM; 3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester,Trimebutine maleate salt; (4a,5a,17b)-4,5-Epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile; 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate maleate; Polybutin; 2a-Cyano-4a,5a-epoxyandrostan-17b-ol-3-one; 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate (2Z)-2-butenedioate (1:1); Desopan; Trilostane; Modrenal; EINECS 251-845-9; (1-Ethyl-1-phenyl-2-(3,4,5-trimethoxybenzoyloxy)ethyl)dimethylammonium hydrogen maleate; Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester, (2Z)-2-butenedioate (1:1); 3,4,5-trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester maleate; TM 906 {Maleate}; Benzoic acid, 3,4,5-trimethoxy-, β-(dimethylamino)-β-ethylphenethyl ester, maleate (1:1)
Molecular FormulaC26H33NO9
Molecular Weight503.54
Purity98%
Density1.3±0.1 g/cm3
Boiling Point497.8±45.0 °C at 760 mmHg
Melting Point122-124ºC
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 34140-59-5 |
| Catalog No. | 2A-9012841 |
| Chinese Name | 马来酸曲美布汀 |
| Synonyms | UNII:2A051GM4YM; 3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester,Trimebutine maleate salt; (4a,5a,17b)-4,5-Epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile; 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate maleate; Polybutin; 2a-Cyano-4a,5a-epoxyandrostan-17b-ol-3-one; 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate (2Z)-2-butenedioate (1:1); Desopan; Trilostane; Modrenal; EINECS 251-845-9; (1-Ethyl-1-phenyl-2-(3,4,5-trimethoxybenzoyloxy)ethyl)dimethylammonium hydrogen maleate; Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester, (2Z)-2-butenedioate (1:1); 3,4,5-trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester maleate; TM 906 {Maleate}; Benzoic acid, 3,4,5-trimethoxy-, β-(dimethylamino)-β-ethylphenethyl ester, maleate (1:1) |
| Molecular Formula | C26H33NO9 |
| Molecular Weight | 503.54 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 497.8±45.0 °C at 760 mmHg |
| Melting Point | 122-124ºC |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | Trimebutine maleate is a compound with antimuscarinic and weak mu opioid receptor agonist effects. |
| HTC | 2922199090 |
| MDL Number | MFCD00133874 |
| SMILES | OC(=O)\C=C/C(O)=O.CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(N(C)C)c2ccccc2 |
| InChI | 1S/C22H29NO5.C4H4O4/c1-7-22(23(2)3,17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5;5-3(6)1-2-4(7)8/h8-14H,7,15H2,1-6H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChI Key | FSRLGULMGJGKGI-BTJKTKAUSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12841_1_34140_59_5.pdf |
| Bioactivity | Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Metabolic Disease References [1]. Kaneto, H., M. Takahashi, and J. Watanabe, The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. J Pharmacobiodyn, 1990. 13(7): p. 448-53. [2]. Roman, F.J., et al., Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther, 1999. 289(3): p. 1391-7. [3]. Hiyama, T., et al., Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol, 2009. 24(4): p. 537-46. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 497.8±45.0 °C at 760 mmHg Melting Point 122-124ºC Molecular Formula C26H33NO9 Molecular Weight 503.54 Flash Point 254.8±28.7 °C PSA 131.83000 LogP 3.61 Vapour Pressure 0.0±2.9 mmHg at 25°C Index of Refraction 1.610 InChIKey FSRLGULMGJGKGI-BTJKTKAUSA-N SMILES CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C.O=C(O)C=CC(=O)O Storage condition 2-8°C |
| Use of | Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3]. Properties Name Trimebutine Maleate Salt Synonym More Synonyms Trimebutine Maleate Biological Activity Description Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Metabolic Disease References [1]. Kaneto, H., M. Takahashi, and J. Watanabe, The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. J Pharmacobiodyn, 1990. 13(7): p. 448-53. [2]. Roman, F.J., et al., Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther, 1999. 289(3): p. 1391-7. [3]. Hiyama, T., et al., Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol, 2009. 24(4): p. 537-46. Chemical & Physical Properties Molecular Formula C26H33NO9 PSA 131.83000 Index of Refraction 1.610 InChIKey FSRLGULMGJGKGI-BTJKTKAUSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 96.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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