CAS Number39133-31-8
Synonymstrimebutine free base; TRIMEBUTIN; 3,4,5-TRIMETHOXYBENZOIC ACID 2-[DIMETHYLAMINO]-2-PHENYLBUTYL ESTER; 3,4,5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL; Trimebutine hydrochloride; 2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL-3',4',5'-TRIMETHOXYBENZOATE; 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate; TRIMEBUTINE; 3,4,5-Trimethoxybenzoic Acid 2-(Dimethylamino)-2-phenylbutyl Ester; hydrogenated maleate of 2-dimethyl-amino-2-phenylbutyl-3,4,5-trimetoxybenzoate; EINECS 254-309-2; MFCD00133873; TRIMEBUTINE3.4.5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL; Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester; trimebutine maleate
Molecular FormulaC22H29O5N1
Molecular Weight387.48
Purity99%
Density1.1±0.1 g/cm3
Boiling Point457.9±34.0 °C at 760 mmHg
Melting Point79ºC
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 39133-31-8 |
| Catalog No. | 2A-9012840 |
| Chinese Name | 曲美布汀 |
| Synonyms | trimebutine free base; TRIMEBUTIN; 3,4,5-TRIMETHOXYBENZOIC ACID 2-[DIMETHYLAMINO]-2-PHENYLBUTYL ESTER; 3,4,5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL; Trimebutine hydrochloride; 2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL-3',4',5'-TRIMETHOXYBENZOATE; 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate; TRIMEBUTINE; 3,4,5-Trimethoxybenzoic Acid 2-(Dimethylamino)-2-phenylbutyl Ester; hydrogenated maleate of 2-dimethyl-amino-2-phenylbutyl-3,4,5-trimetoxybenzoate; EINECS 254-309-2; MFCD00133873; TRIMEBUTINE3.4.5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL; Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester; trimebutine maleate |
| Molecular Formula | C22H29O5N1 |
| Molecular Weight | 387.48 |
| Purity | 99 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 457.9±34.0 °C at 760 mmHg |
| Melting Point | 79ºC |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | 2-8°C |
| Application | Trimebutine is an opioid receptor agonist with antimuscarinic activity. |
| HTC | 2922199090 |
| MDL Number | MFCD00133873 |
| SMILES | CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(N(C)C)c2ccccc2 |
| InChI | InChI=1S/C22H29NO5/c1-7-22(23(2)3,17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5/h8-14H,7,15H2,1-6H3 |
| InChI Key | InChIKey=LORDFXWUHHSAQU-UHFFFAOYSA-N |
| MSDS | msds/12840_1_39133_31_8.pdf |
| Bioactivity | Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Metabolic Disease References [1]. Kaneto, H., M. Takahashi, and J. Watanabe, The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. J Pharmacobiodyn, 1990. 13(7): p. 448-53. [2]. Roman, F.J., et al., Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther, 1999. 289(3): p. 1391-7. [3]. Hiyama, T., et al., Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol, 2009. 24(4): p. 537-46. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 457.9±34.0 °C at 760 mmHg Melting Point 79ºC Molecular Formula C22H29NO5 Molecular Weight 387.469 Flash Point 230.8±25.7 °C Exact Mass 387.204559 PSA 57.23000 LogP 4.34 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.534 Storage condition 2-8°C |
| Use of | Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3]. Properties Articles29 Name 3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester Synonym More Synonyms Trimebutine Biological Activity Description Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Metabolic Disease References [1]. Kaneto, H., M. Takahashi, and J. Watanabe, The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. J Pharmacobiodyn, 1990. 13(7): p. 448-53. [2]. Roman, F.J., et al., Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther, 1999. 289(3): p. 1391-7. [3]. Hiyama, T., et al., Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol, 2009. 24(4): p. 537-46. Chemical & Physical Properties Molecular Formula C22H29NO5 Exact Mass 387.204559 PSA 57.23000 Index of Refraction 1.534 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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