| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4201-22-3 |
| Catalog No. | 2A-9012771 |
| Chinese Name | 托洛尼定 |
| Synonyms | Tolonidina; Tolonidinum; ST-375; Tolonidine; Euctan |
| Molecular Formula | C10H12ClN3 |
| Molecular Weight | 209.67500 |
| Purity | 98.00 |
| Density | 1.31g/cm3 |
| Boiling Point | 314ºC at 760 mmHg |
| Appearance | solid |
| Storage Condition | -20°C, sealed, dry |
| Application | Tolonidine is a derivative of imidazoline. Tolonidine is orally available and has hypotensive and antihypertensive effects. |
| HTC | 2933290090 |
| SMILES | Cc1ccc(NC2=NCCN2)c(Cl)c1 |
| InChI | InChI=1S/C10H12ClN3.HNO3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10;2-1(3)4/h2-3,6H,4-5H2,1H3,(H2,12,13,14);(H,2,3,4) |
| InChI Key | KWBTZIFLQYYPTH-UHFFFAOYSA-N |
| Use of | Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties[1]. Properties Name N-(2-chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine Synonym More Synonyms Tolonidine Biological Activity Description Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others In Vivo In the anesthetized dog, tolonidine administered i.v. decreases the amplitude of ventricular contractions, reduces aortic blood flow and increases peripheral vascular resistances[1]. In the bivagotomized pithed rat, tolonidine induces a long-lasting increase in blood pressure with no secondary hypotension, thus suggesting peripheral sympathomimetic properties[1]. References [1]. Cosnier D, et al. Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis. Arzneimittelforschung. 1975 Nov;25(11):1802-6. Chemical & Physical Properties Exact Mass 209.07200 PSA 36.42000 LogP 1.85690 Index of Refraction 1.637 InChIKey KWBTZIFLQYYPTH-UHFFFAOYSA-N Safety Information HS Code 2933290090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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