CAS Number2398-96-1
SynonymsMethyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester; Tritin; EINECS 219-266-6; O-naphthalen-2-yl methyl(3-methylphenyl)carbamothioate; Dermoxin; Tinavet; Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl ester; Pitrex; sorgoa; Focusan; O-2-Naphthyl methyl(3-methylphenyl)carbamothioate; Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthyl Ester; Timoped; Tinactin; tolnaftate; Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; o-(2-Naphthyl) methyl(3-methylphenyl)thiocarbamate; Aftate
Molecular FormulaC19H17NOS
Molecular Weight307.41
Purity98%
Density1.2±0.1 g/cm3
Boiling Point453.4±38.0 °C at 760 mmHg
Melting Point110.5-111.5ºC
Appearancewhite powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2398-96-1 |
| Catalog No. | 2A-9012769 |
| Chinese Name | 托萘酯 |
| Synonyms | Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester; Tritin; EINECS 219-266-6; O-naphthalen-2-yl methyl(3-methylphenyl)carbamothioate; Dermoxin; Tinavet; Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl ester; Pitrex; sorgoa; Focusan; O-2-Naphthyl methyl(3-methylphenyl)carbamothioate; Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthyl Ester; Timoped; Tinactin; tolnaftate; Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; o-(2-Naphthyl) methyl(3-methylphenyl)thiocarbamate; Aftate |
| Molecular Formula | C19H17NOS |
| Molecular Weight | 307.41 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 453.4±38.0 °C at 760 mmHg |
| Melting Point | 110.5-111.5ºC |
| Appearance | white powder |
| Water Solubility | <0.1 g/100 mL at 22 ºC |
| Storage Condition | 2-8°C |
| Application | Tolnaftate is a synthetic thiocarbamate antifungal compound. |
| HTC | 2930909090 |
| PubChem ID | 329823607 |
| MDL Number | MFCD00056611 |
| SMILES | CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3 |
| InChI | 1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3 |
| InChI Key | FUSNMLFNXJSCDI-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12769_1_2398_96_1.pdf |
| Bioactivity | Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent. Target: AntifungalTolnaftate blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans [1]. Tolnaftate inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid [2]. Related Catalog Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection Natural Products >> Others References [1]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60. [2]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 453.4±38.0 °C at 760 mmHg Melting Point 110.5-111.5ºC Molecular Formula C19H17NOS Molecular Weight 307.409 Flash Point 228.0±26.8 °C Exact Mass 307.103088 PSA 44.56000 LogP 5.15 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.697 InChIKey FUSNMLFNXJSCDI-UHFFFAOYSA-N SMILES Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1 Storage condition 2-8°C Water Solubility <0.1 g/100 mL at 22 ºC |
| Use of | Properties Articles28 Name tolnaftate Synonym More Synonyms tolnaftate Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection Natural Products >> Others References [1]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60. [2]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81. Chemical & Physical Properties Molecular Formula C19H17NOS Exact Mass 307.103088 PSA 44.56000 Index of Refraction 1.697 InChIKey FUSNMLFNXJSCDI-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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