CAS Number40180-04-9
SynonymsTienilic acid; (2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid; Tienilico acido; (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid; Acidum tienilicum; TienilicAcid; Selacryn; Diflurex; Ticrynafen Tienylic acid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid; [2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid; Acido tienilico; Acide tienilique; 2,3-dichloro-4-(thien-2-ylcarbonyl)-phenoxyacetic acid; [2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic acid; [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid; Ticrex; {[2,3-dichloro-4-(2-thienylcarbonyl)phenyl]oxy}acetic acid; Ticrynafen; 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid; Thienylic acid; [2,3-dichloro-4-(thiophen-2-ylcarbonyl)phenoxy]acetic acid
Molecular FormulaC13H8Cl2O4S
Molecular Weight331.17
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point534.6±50.0 °C at 760 mmHg
Melting Point148-149ºC
Appearancepowder
EINECS254-826-3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 40180-04-9 |
| Catalog No. | 2A-9012718 |
| Chinese Name | 替宁酸 |
| Synonyms | Tienilic acid; (2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid; Tienilico acido; (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid; Acidum tienilicum; TienilicAcid; Selacryn; Diflurex; Ticrynafen Tienylic acid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid; [2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid; Acido tienilico; Acide tienilique; 2,3-dichloro-4-(thien-2-ylcarbonyl)-phenoxyacetic acid; [2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic acid; [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid; Ticrex; {[2,3-dichloro-4-(2-thienylcarbonyl)phenyl]oxy}acetic acid; Ticrynafen; 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid; Thienylic acid; [2,3-dichloro-4-(thiophen-2-ylcarbonyl)phenoxy]acetic acid |
| Molecular Formula | C13H8Cl2O4S |
| Molecular Weight | 331.17 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 534.6±50.0 °C at 760 mmHg |
| Melting Point | 148-149ºC |
| Appearance | powder |
| Storage Condition | -20°C |
| Application | Ferric acid is a uric acid diuretic. Thienoic acid has certain liver toxicity [1][3]. |
| EINECS | 254-826-3 |
| HTC | 2934999090 |
| PubChem ID | 329825452 |
| MDL Number | MFCD00867339 |
| SMILES | OC(=O)COc1ccc(c(Cl)c1Cl)C(=O)c2cccs2 |
| InChI | 1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17) |
| InChI Key | AGHANLSBXUWXTB-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12161501 |
| MSDS | msds/12718_1_40180_04_9.pdf |
| Use of | Tienilic acid is a uricosuric diuretic. Tienilic acid possesses certain hepatotoxicity[1][3]. Properties Articles28 Name tienilic acid Synonym More Synonyms Tienilic acid Biological Activity Description Tienilic acid is a uricosuric diuretic. Tienilic acid possesses certain hepatotoxicity[1][3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Lemieux G, et al, Baverel G. Metabolic effects in man of tienilic acid, a new diuretic with uricosuric properties. Nephron. 1978;20(1):54-64. [3]. Oker-Blom C, et al. Toxicological studies on tienilic acid in rats. Toxicol Lett. 1980;6(2):93-99. Chemical & Physical Properties Exact Mass 329.952026 PSA 91.84000 Index of Refraction 1.632 InChIKey AGHANLSBXUWXTB-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Acetic acid, (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)- CAS REGISTRY NUMBER : 40180-04-9 BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C13-H8-Cl2-O4-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T5SJ BVR BG CG DO1VQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : 3571 ug/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : 6666 ug/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - urine volume decreased TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Kidney, Ureter, Bladder - urine volume increased TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) MUTATION DATA TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 100 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,1,1985 Safety Information Hazard Codes Xi RIDADR NONH for all modes of transport RTECS AG9300000 HS Code 2934999090 Precursor & DownStream Precursor 0 DownStream 1 CAS#:55901-78-5 [2,3-Dichloro-4... |
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| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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