CAS Number53885-35-1
Synonyms5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride; MFCD00661081; Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-(o-chlorobenzyl)-, hydrochloride; Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, hydrochloride; 5-(2-Chlorbenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridinhydrochlorid; 5-(2-chlorobenzyl)-4,5,6,7-tétrahydrothiéno[3,2-c]pyridine chlorhydrate; Ticlopidine hydrochloride; 5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine; thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-, hydrochloride; Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-, hydrochloride (1:1); 5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride; 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydroch
Molecular FormulaC14H15Cl2NS
Molecular Weight300.25
Purity≥99%
Boiling Point367.3ºC at 760 mmHg
Melting Point205°C
Appearancewhite powder
EINECS258-837-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53885-35-1 |
| Catalog No. | 2A-9012716 |
| Chinese Name | 盐酸噻氯匹定 |
| Synonyms | 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride; MFCD00661081; Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-(o-chlorobenzyl)-, hydrochloride; Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, hydrochloride; 5-(2-Chlorbenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridinhydrochlorid; 5-(2-chlorobenzyl)-4,5,6,7-tétrahydrothiéno[3,2-c]pyridine chlorhydrate; Ticlopidine hydrochloride; 5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine; thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-, hydrochloride; Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-, hydrochloride (1:1); 5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride; 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydroch |
| Molecular Formula | C14H15Cl2NS |
| Molecular Weight | 300.25 |
| Purity | ≥99 |
| Boiling Point | 367.3ºC at 760 mmHg |
| Melting Point | 205°C |
| Appearance | white powder |
| Water Solubility | Water solubility: soluble; soluble in: methanol; s |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Application | Ticlopidine hydrochloride is an ADP receptor inhibitor with an IC50 of 2 μM for platelet aggregation. |
| EINECS | 258-837-4 |
| HTC | 2934999090 |
| PubChem ID | 329826850 |
| MDL Number | MFCD00079606 |
| SMILES | Cl.Clc1ccccc1CN2CCc3sccc3C2 |
| InChI | 1S/C14H14ClNS.ClH/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14;/h1-4,6,8H,5,7,9-10H2;1H |
| InChI Key | MTKNGOHFNXIVOS-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12716_1_53885_35_1.pdf |
| Bioactivity | Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.Target: Adenosine diphosphate (ADP)Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Ticlopidine hydrochloride inhibits platelet aggregation with IC50 of ~2 μM in men. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. Its niche role as an alternative in those patients who do not tolerate Clopidogrel has now been superdeded by Ticagrelor and Prasugrel. The usual dose is 250 mg twice daily by the oral route.Ticlopidine hydrochloride, when orally administered to rats, results in activation of basal and prostaglandin E1 (PGE1)-stimulated adenylate cylase activity through increase in affinity of the cyclase in platelet membrane to PGE1, although it failed to affect adenosine- or sodium fluoride-stimulated activity of the enzyme. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Cardiovascular Disease References [1]. Thebault JJ, et al. Effects of ticlopidine, a new platelet aggregation inhibitor in man. Clin Pharmacol Ther. 1975 Oct;18(4):485-90. [2]. Ashida SI, et al. Mode of action of ticlopidine in inhibition of platelet aggregation in the rat. Thromb Haemost. 1979 Apr 23;41(2):436-49. Chemical & Physical Properties Boiling Point 367.3ºC at 760 mmHg Melting Point 205°C Molecular Formula C14H15Cl2NS Molecular Weight 300.247 Flash Point 175.9ºC Exact Mass 299.030212 PSA 31.48000 LogP 4.69970 InChIKey MTKNGOHFNXIVOS-UHFFFAOYSA-N SMILES Cl.Clc1ccccc1CN1CCc2sccc2C1 |
| Use of | Properties Articles98 Name ticlopidine hydrochloride Synonym More Synonyms Ticlopidine Hydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Cardiovascular Disease References [1]. Thebault JJ, et al. Effects of ticlopidine, a new platelet aggregation inhibitor in man. Clin Pharmacol Ther. 1975 Oct;18(4):485-90. [2]. Ashida SI, et al. Mode of action of ticlopidine in inhibition of platelet aggregation in the rat. Thromb Haemost. 1979 Apr 23;41(2):436-49. Chemical & Physical Properties Exact Mass 299.030212 PSA 31.48000 LogP 4.69970 InChIKey MTKNGOHFNXIVOS-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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