| Chemical & Physical Properties | |
|---|---|
| CAS Number | 31428-61-2 |
| Catalog No. | 2A-9012702 |
| Chinese Name | 噻美尼定. |
| Synonyms | Hoe-440; Tiamenidinum; Hoe-42-440; Tiamenidine; Tiamenidina |
| Molecular Formula | C8H10ClN3S |
| Molecular Weight | 215.70 |
| Purity | 98.00 |
| Density | 1.52g/cm3 |
| Boiling Point | 305.1ºC at 760mmHg |
| Melting Point | 152° |
| Application | Thiocyanamide (HOE440) is an orally active α2-adrenergic receptor agonist with antihypertensive effects. Thiocyanamide is used as an antihypertensive agent in hypertension research [1]. |
| HTC | 2934999090 |
| SMILES | Cc1csc(Cl)c1NC1=NCCN1 |
| InChI | InChI=1S/C8H10ClN3S.ClH/c1-5-4-13-7(9)6(5)12-8-10-2-3-11-8;/h4H,2-3H2,1H3,(H2,10,11,12);1H |
| InChI Key | CVWILQHZFWRYPB-UHFFFAOYSA-N |
| Use of | Tiamenidine (HOE 440) is an orally active α2-adrenergic receptor agonist with antihypertensive effect. Tiamenidine is used as an antihypertensive agent for hypertension research[1]. Properties Name N-(2-chloro-4-methylthiophen-3-yl)-4,5-dihydro-1H-imidazol-2-amine Synonym More Synonyms Tiamenidine Biological Activity Description Tiamenidine (HOE 440) is an orally active α2-adrenergic receptor agonist with antihypertensive effect. Tiamenidine is used as an antihypertensive agent for hypertension research[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor IC50: α2-Adrenergic Receptor[1] References [1]. D M Roden, et al. Electrophysiologic and hemodynamic effects of chronic oral therapy with the alpha 2-agonists clonidine and tiamenidine in hypertensive volunteers. Clin Pharmacol Ther. 1988 Jun;43(6):648-54. Chemical & Physical Properties Exact Mass 215.02800 PSA 64.66000 LogP 1.91840 Index of Refraction 1.717 InChIKey CVWILQHZFWRYPB-UHFFFAOYSA-N Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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