CAS Number136-47-0
Synonyms4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Ameth; Tetracaine (hydrochloride); Tetracaine HCl; MFCD00038912; curtacain; EINECS 205-248-5; PANTOCAINE; decicaine; anethaine; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Amethocaine hydrochloride; anacel; butethanol; tonexol; decicain; menonasal
Molecular FormulaC15H25ClN2O2
Molecular Weight300.82
Purity≥99%
Boiling Point389.4ºC at 760 mmHg
Melting Point149°C
AppearanceWhite or off-white crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 136-47-0 |
| Catalog No. | 2A-9012654 |
| Chinese Name | 盐酸丁卡因 |
| Synonyms | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Ameth; Tetracaine (hydrochloride); Tetracaine HCl; MFCD00038912; curtacain; EINECS 205-248-5; PANTOCAINE; decicaine; anethaine; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Amethocaine hydrochloride; anacel; butethanol; tonexol; decicain; menonasal |
| Molecular Formula | C15H25ClN2O2 |
| Molecular Weight | 300.82 |
| Purity | ≥99 |
| Boiling Point | 389.4ºC at 760 mmHg |
| Melting Point | 149°C |
| Appearance | White or off-white crystalline powder |
| Storage Condition | Refrigerator |
| Packaging | III |
| Application | Tetracaine hydrochloride is an allosteric inhibitor of calcium channels. |
| HTC | 2942000000 |
| PubChem ID | 57654697 |
| MDL Number | MFCD00038912 |
| SMILES | Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C |
| InChI | 1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H |
| InChI Key | PPWHTZKZQNXVAE-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1 |
| MSDS | msds/12654_1_136_47_0.pdf |
| Bioactivity | Tetracaine HCl is a potent local anaesthetic and a channel function allosteric inhibitor.Target: Calcium ChannelTetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely [1, 2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease References [1]. http://en.wikipedia.org/wiki/Tetracaine [2]. http://www.ncbi.nlm.nih.gov/pubmed/9147318 Chemical & Physical Properties Boiling Point 389.4ºC at 760 mmHg Melting Point 149°C Molecular Formula C15H25ClN2O2 Molecular Weight 300.824 Flash Point 189.3ºC Exact Mass 300.160461 PSA 41.57000 LogP 3.49200 Vapour Pressure 2.87E-06mmHg at 25°C InChIKey PPWHTZKZQNXVAE-UHFFFAOYSA-N SMILES CCCCNc1ccc(C(=O)OCCN(C)C)cc1.Cl Storage condition Refrigerator |
| Use of | Tetracaine HCl is a potent local anaesthetic and a channel function allosteric inhibitor.Target: Calcium ChannelTetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely [1, 2]. Properties Articles43 Name Tetracaine hydrochloride Synonym More Synonyms Tetracaine hydrochloride Biological Activity Description Tetracaine HCl is a potent local anaesthetic and a channel function allosteric inhibitor.Target: Calcium ChannelTetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely [1, 2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease References [1]. http://en.wikipedia.org/wiki/Tetracaine [2]. http://www.ncbi.nlm.nih.gov/pubmed/9147318 Chemical & Physical Properties Exact Mass 300.160461 PSA 41.57000 LogP 3.49200 InChIKey PPWHTZKZQNXVAE-UHFFFAOYSA-N Storage condition Refrigerator |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (p-(Butylamino)-benzoic acid 2-(dimethylamino)ethyl ester monohydrochloride) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (p-(Butylamino)-benzoic acid 2-(dimethylamino)ethyl ester monohydrochloride) International air transport hazard regulations: Toxic solid, organic, n.o.s. (p-(Butylamino)-benzoic acid 2-(dimethylamino)ethyl ester monohydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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