| Chemical & Physical Properties | |
|---|---|
| CAS Number | 128-57-4 |
| Catalog No. | 2A-9012421 |
| Chinese Name | 番泻苷B |
| Synonyms | SennosideB; Sennoside B; EINECS 204-895-0; MFCD00151528 |
| Molecular Formula | C42H38O20 |
| Molecular Weight | 862.74 |
| Purity | 98 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 1144.8±65.0 °C at 760 mmHg |
| Appearance | light yellow crystal |
| Storage Condition | Store in a sealed, dry place away from light. |
| Application | Sennoside B is an anthraquinone glycoside found in large amounts in the leaves and pods of senna (Cassia angustifolia). Sennoside B inhibits PDGF-stimulated cell proliferation by binding to PDGF-BB an |
| MDL Number | MFCD00151528 |
| SMILES | OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O |
| InChI | 1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26+,31-,32-,35+,36+,37-,38-,41-,42?/m1/s1 |
| InChI Key | IPQVTOJGNYVQEO-OVYIKYHGSA-N |
| Beilstein/REAXYS | 5723747 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12421_1_128_57_4.pdf |
| Bioactivity | Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR References [1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [2]. Chen YC, et al. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 1144.8±65.0 °C at 760 mmHg Molecular Formula C42H38O20 Molecular Weight 862.739 Flash Point 348.6±27.8 °C Exact Mass 862.195618 PSA 347.96000 LogP 1.88 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.763 InChIKey IPQVTOJGNYVQEO-AIFLABODSA-N SMILES O=C(O)c1cc(O)c2c(c1)C(C1c3cc(C(=O)O)cc(O)c3C(=O)c3c(OC4OC(CO)C(O)C(O)C4O)cccc31)c1cccc(OC3OC(CO)C(O)C(O)C3O)c1C2=O |
| Use of | Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[2]. Properties Articles25 Name sennoside B Synonym More Synonyms Sennoside B Biological Activity Description Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR References [1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [2]. Chen YC, et al. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22. Chemical & Physical Properties Molecular Formula C42H38O20 Exact Mass 862.195618 PSA 347.96000 Index of Refraction 1.763 InChIKey IPQVTOJGNYVQEO-AIFLABODSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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