CAS Number2469-34-3
SynonymsTennifolsaeure; 12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid,Tenuigenin; Senegenin; tenuifolic acid; (2b,3b,4a,12a)-12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid; Tenuifolsaeure; Senegin
Molecular FormulaC30H45ClO6
Molecular Weight537.13
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point674.1±55.0 °C at 760 mmHg
Melting Point290-292ºC
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2469-34-3 |
| Catalog No. | 2A-9012417 |
| Chinese Name | 远志皂苷元 |
| Synonyms | Tennifolsaeure; 12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid,Tenuigenin; Senegenin; tenuifolic acid; (2b,3b,4a,12a)-12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid; Tenuifolsaeure; Senegin |
| Molecular Formula | C30H45ClO6 |
| Molecular Weight | 537.13 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 674.1±55.0 °C at 760 mmHg |
| Melting Point | 290-292ºC |
| Appearance | powder |
| Storage Condition | 2-8C |
| Application | Tenuigenin is the main active ingredient isolated from the roots of the Chinese herb Polygala tenuifolia. Tenuigenin prevents Staphylococcus aureus-induced pneumonia by inhibiting NF-κB activation. |
| PubChem ID | 329825628 |
| MDL Number | MFCD00466906 |
| SMILES | [H][C@]12[C@](CCC3=C2[C@@H](CCl)C[C@@]4([H])[C@@]3(C)CC[C@]5([H])[C@]4(C)C[C@H](O)[C@H](O)[C@]5(C(O)=O)C)(C(O)=O)CCC(C)(C)C1 |
| InChI | 1S/C30H45ClO6/c1-26(2)10-11-30(25(36)37)9-6-17-22(18(30)13-26)16(15-31)12-21-27(17,3)8-7-20-28(21,4)14-19(32)23(33)29(20,5)24(34)35/h16,18-21,23,32-33H,6-15H2,1-5H3,(H,34,35)(H,36,37)/t16-,18+,19+,20-,21+,23+,27+,28+,29+,30-/m1/s1 |
| InChI Key | CWHJIJJSDGEHNS-MYLFLSLOSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/12417_1_2469_34_3.pdf |
| Bioactivity | Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect[1]. Related Catalog Research Areas >> Infection Research Areas >> Inflammation/Immunology Target NF-κB In Vivo Tenuigenin (2, 4, 8 mg/kg) significantly attenuates S.aureus-induced lung histopathological changes. Tenuigenin also inhibits lung wet/dry (W/D) ratio, and inflammatory cytokines TNF-α and IL-1β production in Male BALB/c mice[1]. References [1]. Yu B, et al. Protective effects of tenuigenin on Staphylococcus aureus-induced pneumonia in mice. Microb Pathog. 2017 Sep;110:385-389. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 674.1±55.0 °C at 760 mmHg Melting Point 290-292ºC Molecular Formula C30H45ClO6 Molecular Weight 537.128 Flash Point 361.5±31.5 °C Exact Mass 536.290466 PSA 115.06000 LogP 6.39 Vapour Pressure 0.0±4.7 mmHg at 25°C Index of Refraction 1.591 InChIKey CWHJIJJSDGEHNS-MYLFLSLOSA-N SMILES CC1(C)CCC2(C(=O)O)CCC3=C(C(CCl)CC4C3(C)CCC3C4(C)CC(O)C(O)C3(C)C(=O)O)C2C1 Storage condition 2-8C |
| Use of | Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect[1]. Properties Name 13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid Synonym More Synonyms Senegenin Biological Activity Description Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect[1]. Related Catalog Research Areas >> Infection Research Areas >> Inflammation/Immunology References [1]. Yu B, et al. Protective effects of tenuigenin on Staphylococcus aureus-induced pneumonia in mice. Microb Pathog. 2017 Sep;110:385-389. Chemical & Physical Properties Exact Mass 536.290466 PSA 115.06000 Index of Refraction 1.591 InChIKey CWHJIJJSDGEHNS-MYLFLSLOSA-N |
| Transport Info | Product Name: Polygala saponin |
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