CAS Number91296-87-6
Synonyms6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,hydrochloride; MFCD03427297
Molecular FormulaC20H18ClF2N3O3
Molecular Weight421.83 (anhydrous basis)
Purity99%
Density1.4±0.1 g/cm3
Boiling Point621.4±55.0 °C at 760 mmHg
Melting Point275ºC
AppearanceWhite to yellow crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 91296-87-6 |
| Catalog No. | 2A-9012394 |
| Chinese Name | 盐酸沙拉沙星 |
| Synonyms | 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,hydrochloride; MFCD03427297 |
| Molecular Formula | C20H18ClF2N3O3 |
| Molecular Weight | 421.83 (anhydrous basis) |
| Purity | 99 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 621.4±55.0 °C at 760 mmHg |
| Melting Point | 275ºC |
| Appearance | White to yellow crystalline solid |
| Storage Condition | Refrigerated at 0-6°C |
| Application | Sarafloxacin hydrochloride is an antibacterial compound. |
| HTC | 2933990090 |
| PubChem ID | 24860273 |
| MDL Number | MFCD03427297 |
| SMILES | Fc1ccc(cc1)N2c3c(cc(c(c3)N4CCNCC4)F)C(=O)C(=C2)C(=O)O.[Cl-].[H+] |
| InChI | 1S/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24;/h1-4,9-11,23H,5-8H2,(H,27,28);1H |
| InChI Key | KNWODGJQLCISLC-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12394_1_91296_87_6.pdf |
| Bioactivity | Sarafloxacin hydrochloride is a quinolone antibiotic drug.Target: Antibacterialsarafloxacin hydrochloride is a fluoroquinolone antibiotic registered for use against poultry diseases. Sarafloxacin treatment demonstrated mineralization to 14CO2 amounting to 0.58%, 0.49%, and 0.57% in loam, silt loam, and sandy loam soils, respectively, at the termination of the test [1]. The inhibitory level of sarafloxacin for the tested bacteria was strain dependent. It appeared that in broth culture Escherichia coli isolates were sensitive to sarafloxacin concentrations 5-fold lower than the concentrations present in the simulated gut model, suggesting that sarafloxacin may be partially unavailable due to absorption to organic matter in the model [2]. Administering Sarafloxacin hydrochloride in the feed for 5 d at a dose of 10 or 12.5 mg/kg of fish proved efficacious in treating channel catfish infected with E. ictaluri in all three field trials. Average survival of the nonmedicated group was 43% in trial 1, 11°% in trial 2, and 59% in trial 3. Survival of the corresponding Sarafloxacin hydrochloride-medicated groups averaged 68, 48, and 73%. Antibiotic therapy with Sarafloxacin hydrochloride significantly (P < 0.05) improved survival in all trials [3]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Marengo, J.R., et al., Aerobic biodegradation of (14C)-sarafloxacin hydrochloride in soil. Environmental Toxicology and Chemistry, 1997. 16(3): p. 462-471. [2]. McConville, M.L., et al., Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q, 1995. 17(1): p. 1-5. [3]. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 621.4±55.0 °C at 760 mmHg Melting Point 275ºC Molecular Formula C20H18ClF2N3O3 Molecular Weight 421.83 Flash Point 329.6±31.5 °C PSA 74.57000 LogP 2.09 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.633 InChIKey KNWODGJQLCISLC-UHFFFAOYSA-N SMILES Cl.O=C(O)c1cn(-c2ccc(F)cc2)c2cc(N3CCNCC3)c(F)cc2c1=O Storage condition 0-6°C |
| Use of | Properties Name Sarafloxacin Hydrochloride Synonym More Synonyms Sarafloxacin hydrochloride Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [2]. McConville, M.L., et al., Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q, 1995. 17(1): p. 1-5. [3]. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251. Chemical & Physical Properties PSA 74.57000 Index of Refraction 1.633 InChIKey KNWODGJQLCISLC-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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