| Chemical & Physical Properties | |
|---|---|
| CAS Number | 147098-20-2 |
| Catalog No. | 2A-9012347 |
| Chinese Name | 瑞舒伐他汀钙 |
| Synonyms | MFCD04112702; Crestor; Rosuvastatin Calcium; Rosuvastatin (Calcium) |
| Molecular Formula | C22H27Ca0.5FN3O6S |
| Molecular Weight | 1001.14 |
| Purity | 99 |
| Boiling Point | 745.6ºC at 760 mmHg |
| Melting Point | 122ºC |
| Appearance | powder |
| Storage Condition | -20°C Freezer |
| Application | Rosuvastatin calcium salt is an HMG-CoA reductase inhibitor with an IC50 of 11 nM. |
| HTC | 2935009090 |
| SMILES | [Ca+2].Fc3ccc(cc3)c4nc(nc(c4\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])C(C)C)N([S](=O)(=O)C)C.Fc1ccc(cc1)c2nc(nc(c2\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])C(C)C)N([S](=O)(=O)C)C |
| InChI | 1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;;+2/p-2/b2*10-9+;/t2*16-,17-;/m11./s1 |
| InChI Key | LALFOYNTGMUKGG-BGRFNVSISA-L |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12347_1_147098_20_2.pdf |
| Use of | Properties Name Rosuvastatin Calcium Synonym More Synonyms Rosuvastatin Calcium Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Metabolic Disease References [1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. [2]. Kim, Y.S., et al., Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. J Cardiovasc Pharmacol, 2007. 49(6): p. 376-83. [3]. Carswell, C.I., G.L. Plosker, and B. Jarvis, Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7. [4]. Stalker, T.J., A.M. Lefer, and R. Scalia, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001. 133(3): p. 406-12. [5]. Schneck, D.W., et al., The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther, 2004. 75(5): p. 455-63. Chemical & Physical Properties PSA 304.26000 LogP 4.29560 InChIKey XDIJJHVJIZNZGO-DHMAKVBVSA-N Safety Information Hazard Codes Xi RIDADR NONH for all modes of transport HS Code 2935009090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Rivastigmine tartrate | 129101-54-8 | 2A-9012323 |
| Rofecoxib | 162011-90-7 | 2A-9012330 |
| Rolitetracycline | 751-97-3 | 2A-9012333 |
| Rosiglitazone | 122320-73-4 | 2A-9012344 |
| Rosuvastatin | 287714-41-4 | 2A-9012346 |
| Saquinavir | 127779-20-8 | 2A-9012391 |
| Saquinavir mesylate | 149845-06-7 | 2A-9012392 |
| Sertraline | 79617-96-2 | 2A-9012427 |
| Sildenafil | 139755-83-2 | 2A-9012439 |
| Sildenafil citrate | 171599-83-0 | 2A-0200391 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS