CAS Number6151-25-3
Synonyms4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-, hydrate (1:2); EINECS 204-187-1; MFCD00149487; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one dihydrate; 3,3',4',5,7-Pentahydroxyflavone dihydrate
Molecular FormulaC15H14O9
Molecular Weight338.27
Purity98%
Boiling Point642.4ºC at 760 mmHg
Melting Point>300 °C (lit.)
Appearanceyellow solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6151-25-3 |
| Catalog No. | 2A-9012223 |
| Chinese Name | 二水槲皮素 |
| Synonyms | 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-, hydrate (1:2); EINECS 204-187-1; MFCD00149487; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one dihydrate; 3,3',4',5,7-Pentahydroxyflavone dihydrate |
| Molecular Formula | C15H14O9 |
| Molecular Weight | 338.27 |
| Purity | 98 |
| Boiling Point | 642.4ºC at 760 mmHg |
| Melting Point | >300 °C (lit.) |
| Appearance | yellow solid |
| Water Solubility | practically insoluble |
| Storage Condition | Sealed, cool and dry place to ensure good ventilat |
| Packaging | III |
| Application | Quercetin (dihydrate) is a natural flavonoid that can activate or inhibit the activity of many proteins. Quercetin (dihydrate) can activate SIRT1 and inhibit PI3K. The IC50 values for inhibiting PI3 |
| HTC | 2918290000 |
| MDL Number | MFCD00149487 |
| SMILES | OC(C(O)=C1)=CC=C1C2=C(O)C(C3=C(O)C=C(O)C=C3O2)=O |
| InChI | 1S/C15H10O7.2H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;;/h1-5,16-19,21H;2*1H2 |
| InChI Key | GMGIWEZSKCNYSW-UHFFFAOYSA-N |
| Beilstein/REAXYS | 317313 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1 |
| MSDS | msds/12223_1_6151_25_3.pdf |
| Bioactivity | Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1]. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Target PI3Kγ:2.4 μM (IC50) PI3Kβ:5.4 μM (IC50) PI3Kδ:3.0 μM (IC50) In Vitro Quercetin (dihydrate) is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits[1]. Quercetin (dihydrate) is a PI3K inhibitor with IC50s of 2.4-5.4 μM. Quercetin dihydrate (Sophoretin dihydrate) strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2[1]. Quercetin (dihydrate) inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation[2]. References [1]. Navarro-Núñez L, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. [2]. Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81. [3]. Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277. Chemical & Physical Properties Boiling Point 642.4ºC at 760 mmHg Melting Point >300 °C(lit.) Molecular Formula C15H14O9 Molecular Weight 338.266 Exact Mass 338.063782 PSA 149.82000 LogP 1.85940 InChIKey GMGIWEZSKCNYSW-UHFFFAOYSA-N SMILES O.O.O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 Water Solubility practically insoluble |
| Use of | Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1]. Properties Articles200 Name Quercetin dihydrate Synonym More Synonyms Quercetin dihydrate Biological Activity Description Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1]. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> PI3K PI3Kγ:2.4 μM (IC50) PI3Kβ:5.4 μM (IC50) PI3Kδ:3.0 μM (IC50) References [1]. Navarro-Núñez L, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. [2]. Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81. Chemical & Physical Properties Molecular Formula C15H14O9 Exact Mass 338.063782 PSA 149.82000 LogP 1.85940 InChIKey GMGIWEZSKCNYSW-UHFFFAOYSA-N Water Solubility practically insoluble |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Supervision conditions A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
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