CAS Number117-39-5
SynonymsEINECS 204-187-1; MELETIN; 2',3,4',5,7-pentahydroxyflavone; MFCD00006828; QUERTINE; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; Sophretin; QUERCETOL; QUERCETINE; SOPHORETIN; 3,3',4',5,7-Pentahydroxyflavone; Quercetin; QUERCITIN; kvercetin; 3,3',4',5,7-pentahydroxylflavone
Molecular FormulaC15H10O7
Molecular Weight302.24
Purity≥95 (HPLC)%
Density1.8±0.1 g/cm3
Boiling Point642.4±55.0 °C at 760 mmHg
Melting Point316.5 °C
Appearancesolid
EINECS204-187-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 117-39-5 |
| Catalog No. | 2A-9012222 |
| Chinese Name | 槲皮素 |
| Synonyms | EINECS 204-187-1; MELETIN; 2',3,4',5,7-pentahydroxyflavone; MFCD00006828; QUERTINE; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; Sophretin; QUERCETOL; QUERCETINE; SOPHORETIN; 3,3',4',5,7-Pentahydroxyflavone; Quercetin; QUERCITIN; kvercetin; 3,3',4',5,7-pentahydroxylflavone |
| Molecular Formula | C15H10O7 |
| Molecular Weight | 302.24 |
| Purity | ≥95 (HPLC) |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 642.4±55.0 °C at 760 mmHg |
| Melting Point | 316.5 °C |
| Appearance | solid |
| Water Solubility | <0.1 g/100 mL at 21 ºC |
| Storage Condition | Brown glass bottle with light-sealed packaging. St |
| Packaging | III |
| Application | Quercetin is a natural flavonoid that can activate or inhibit the activity of many proteins. Quercetin can activate SIRT1 and also inhibit PI3K. The IC50 for inhibiting PI3K γ, PI3K δ, and PI3K β is 2 |
| EINECS | 204-187-1 |
| HTC | 2932999099 |
| UN(IATA) | 2811 |
| PubChem ID | 329823865 |
| SMILES | OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1 |
| InChI | 1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H |
| InChI Key | REFJWTPEDVJJIY-UHFFFAOYSA-N |
| Beilstein/REAXYS | 317313 |
| NACRES Code | NA.77 |
| UNSPSC | 12352207 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/12222_1_117_39_5.pdf |
| Bioactivity | Quercetin is a natural flavonoid which activates or inhibits the activities of a number of proteins. Quercetin can activate SIRT1 and inhibit PI3K with IC50s of 2.4 μM, 3.0 μM, 5.4 μM for PI3K γ, PI3K δ and PI3K β, respecti Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Natural Products >> Flavonoids Research Areas >> Cancer Target PI3Kβ:5.4 μM (IC50) PI3Kδ:2.4 μM (IC50) PI3Kγ:3 μM (IC50) Autophagy Mitophagy In Vitro Quercetin is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM. It strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2[1]. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation[2]. In Vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth[3]. Animal Admin Mice are inoculated subcutaneously with 5×105 PC-3 cells suspended in 100μL PBS and 2×108 LNCaP cells suspended in 100μL of matrigel and PBS mixture (1:1) on the right back. When xenograft tumors reach a volume of approximately 100 mm3, mice are randomLy assigned to four groups (n=8 each group) and treated intraperitoneally. Therapeutic schedule based on our in vitro results, preliminary experiments and many other researchers' studies is as follows: (1) Vehicle control group: vehicle of quercetin on day 1, vehicle of 2-ME on day 2, (2) Quercetin treated group: quercetin 75 mg/kg on day 1, vehicle of 2-ME on day 2, (3) 2-ME treated group: vehicle of quercetin on day 1, 2-ME 150 mg/kg on day 2, (4) Combination treatment group: quercetin 75 mg/kg on day 1, 2-ME 150 mg/kg on day 2. Two days is a treatment cycle and the whole treatment process lasted for 4 weeks. Tumor sizes are monitored every 2 days using caliper and tumor volume are calculated according to the formula: L×S2×0.5, in which L represents the longest diameter and S represents the shortest diameter of tumor. Mice are weighed as well. At the end of treatment procedure, on day 29, mice are anesthetized with chloral hydrate and sacrificed by cervical dislocation. Xenograft tumors are taken out quickly and weighed. One part of it is put into liquid nitrogen immediately for future biomarker analysis and the other part is fixed in 10% neutral buffered formalin for immunohistochemical analysis. Serum biochemical parameters such as ALT, AST, creatinine and urea nitrogen that reflected drug toxicity are also detected. References [1]. Navarro-Nú?ez L, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. [2]. Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81. [3]. Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277. Chemical & Physical Properties Density 1.8±0.1 g/cm3 Boiling Point 642.4±55.0 °C at 760 mmHg Melting Point 314-317°C Molecular Formula C15H10O7 Molecular Weight 302.236 Flash Point 248.1±25.0 °C Exact Mass 302.042664 PSA 131.36000 LogP 2.08 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.823 InChIKey REFJWTPEDVJJIY-UHFFFAOYSA-N SMILES O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 Storage condition Store at 0-5°C Water Solubility <0.1 g/100 mL at 21 ºC |
| Use of | Quercetin is a natural flavonoid which activates or inhibits the activities of a number of proteins. Quercetin can activate SIRT1 and inhibit PI3K with IC50s of 2.4 μM, 3.0 μM, 5.4 μM for PI3K γ, PI3K δ and PI3K β, respecti Properties Articles470 Name quercetin Synonym More Synonyms Quercetin Biological Activity Description Quercetin is a natural flavonoid which activates or inhibits the activities of a number of proteins. Quercetin can activate SIRT1 and inhibit PI3K with IC50s of 2.4 μM, 3.0 μM, 5.4 μM for PI3K γ, PI3K δ and PI3K β, respecti Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Natural Products >> Flavonoids Research Areas >> Cancer PI3Kβ:5.4 μM (IC50) PI3Kδ:2.4 μM (IC50) PI3Kγ:3 μM (IC50) References [1]. Navarro-Nú?ez L, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. [2]. Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81. Chemical & Physical Properties Molecular Formula C15H10O7 Exact Mass 302.042664 PSA 131.36000 Index of Refraction 1.823 InChIKey REFJWTPEDVJJIY-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (3,3',4',5,7-Pentahydroxyflavone) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (3,3',4',5,7-Pentahydroxyflavone) International air transport hazard regulations: Toxic solid, organic, n.o.s. (3,3',4',5,7-Pentahydroxyflavone) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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