CAS Number3605-01-4
Synonyms2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine; 2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine; Piribedilum [INN-Latin]; 1-(2''-Pyrimidyl)-4-(methylene-3',4'-dioxybenzyl)piperazine; 2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-pyrimidine; Piribedile [DCIT]; 3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine; 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine; Piribedil; ET 495; Trivastal; MFCD00868264; Trivastan; EU-4200; EINECS 222-764-6; 2-[4-(3,4-Methylenedioxybenzyl)piperazino]pyrimidine
Molecular FormulaC16H18N4O2
Molecular Weight298.347
Purity98%
Density1.3±0.1 g/cm3
Boiling Point469.4±55.0 °C at 760 mmHg
Melting Point98 °C
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3605-01-4 |
| Catalog No. | 2A-9012044 |
| Chinese Name | 吡贝地尔 |
| Synonyms | 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine; 2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine; Piribedilum [INN-Latin]; 1-(2''-Pyrimidyl)-4-(methylene-3',4'-dioxybenzyl)piperazine; 2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-pyrimidine; Piribedile [DCIT]; 3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine; 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine; Piribedil; ET 495; Trivastal; MFCD00868264; Trivastan; EU-4200; EINECS 222-764-6; 2-[4-(3,4-Methylenedioxybenzyl)piperazino]pyrimidine |
| Molecular Formula | C16H18N4O2 |
| Molecular Weight | 298.347 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 469.4±55.0 °C at 760 mmHg |
| Melting Point | 98 °C |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | 2-8°C |
| Application | Piribedil is a dopamine D2 receptor (D2R) agonist that also exhibits antagonistic effects on hα1A-adrenergic receptors (hα1A-AR). |
| HTC | 2934999090 |
| MDL Number | MFCD00868264 |
| SMILES | c1cnc(N2CCN(Cc3ccc4c(c3)OCO4)CC2)nc1 |
| InChI | InChI=1S/C16H18N4O2.CH4O3S/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14;1-5(2,3)4/h1-5,10H,6-9,11-12H2;1H3,(H,2,3,4) |
| InChI Key | OQDPVLVUJFGPGQ-UHFFFAOYSA-N |
| MSDS | msds/12044_1_3605_01_4.pdf |
| Bioactivity | Piribedil is a dopamine D2 receptor (D2R) agonist which also displays antagonist property at hα1A-adrenoceptor (hα1A-AR). Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Target D2R, hα1A-AR[1] References [1]. Mark J. Milla, et al. Antiparkinsonian Agent Piribedil Displays Antagonist Properties at Native, Rat, and Cloned, Human α2 -Adrenoceptors: Cellular and Functional Characterization. JPET, 2001, 297 (3) 876-887. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 469.4±55.0 °C at 760 mmHg Melting Point 98 °C Molecular Formula C16H18N4O2 Molecular Weight 298.340 Flash Point 237.7±31.5 °C Exact Mass 298.142975 PSA 50.72000 LogP 2.36 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.632 InChIKey OQDPVLVUJFGPGQ-UHFFFAOYSA-N SMILES c1cnc(N2CCN(Cc3ccc4c(c3)OCO4)CC2)nc1 Storage condition 2-8°C |
| Use of | Piribedil is a dopamine D2 receptor (D2R) agonist which also displays antagonist property at hα1A-adrenoceptor (hα1A-AR). Properties Name 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Synonym More Synonyms Piribedil Biological Activity Description Piribedil is a dopamine D2 receptor (D2R) agonist which also displays antagonist property at hα1A-adrenoceptor (hα1A-AR). Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease D2R, hα1A-AR[1] References [1]. Mark J. Milla, et al. Antiparkinsonian Agent Piribedil Displays Antagonist Properties at Native, Rat, and Cloned, Human α2 -Adrenoceptors: Cellular and Functional Characterization. JPET, 2001, 297 (3) 876-887. Chemical & Physical Properties Molecular Formula C16H18N4O2 Exact Mass 298.142975 PSA 50.72000 Index of Refraction 1.632 InChIKey OQDPVLVUJFGPGQ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Pirbedil Modification Number: 5 |
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