CAS Number88069-67-4
SynonymsPilzicainide; Pilsicainide HCl; Pilsicainida [INN-Spanish]; n-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide; Pilsicainidum [INN-Latin]; Pilsicainide; Pilsicainide [INN]
Molecular FormulaC17H24N2O
Molecular Weight272.39 (free base basis)
Purity≥98 (HPLC)%
Density1.11 g/cm3
Boiling Point416.9ºC at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 88069-67-4 |
| Catalog No. | 2A-9012019 |
| Chinese Name | 吡西卡尼 |
| Synonyms | Pilzicainide; Pilsicainide HCl; Pilsicainida [INN-Spanish]; n-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide; Pilsicainidum [INN-Latin]; Pilsicainide; Pilsicainide [INN] |
| Molecular Formula | C17H24N2O |
| Molecular Weight | 272.39 (free base basis) |
| Purity | ≥98 (HPLC) |
| Density | 1.11 g/cm3 |
| Boiling Point | 416.9ºC at 760 mmHg |
| Appearance | powder |
| Storage Condition | room temp |
| Application | Pixicatide (SUN 1165 free acid) is a potent sodium channel blocker and a potent Class Ic antiarrhythmic agent [1][2]. |
| HTC | 2933990090 |
| PubChem ID | 329819981 |
| MDL Number | MFCD00903769 |
| SMILES | Cl.Cc1cccc(C)c1NC(=O)CC23CCCN2CCC3 |
| InChI | 1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H |
| InChI Key | NZOSVDHCTCLGEB-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/12019_1_88069_67_4.pdf |
| Use of | Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent[1][2]. Properties Name N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide Synonym More Synonyms pilsicainide Biological Activity Description Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease In Vitro Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1]. Chemical & Physical Properties Molecular Formula C17H24N2O Exact Mass 272.18900 PSA 32.34000 LogP 3.27130 Index of Refraction 1.581 InChIKey BCQTVJKBTWGHCX-UHFFFAOYSA-N Storage condition room temp Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1H-Pyrrolizine-7a(5H)-acetamide, tetrahydro-N-(2,6-dimethylphenyl)-, hydrochloride, hemihydrate CAS REGISTRY NUMBER : 88069-67-4 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,769,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,769,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,769,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,769,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,769,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,769,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,769,1991 Safety Information Hazard Codes Xn Risk Phrases 22 HS Code 2933990090 Synthetic Route Tetrahydro-1H-p... CAS#:88069-56-1 2,6-xylidine CAS#:87-62-7 pilsicainide CAS#:88069-67-4 Literature: Journal of Medicinal Chemistry, , vol. 28, # 6 p. 714 - 717 (Tetrahydro-pyr... CAS#:100445-98-5 2,6-xylidine CAS#:87-62-7 pilsicainide CAS#:88069-67-4 Literature: Journal of Medicinal Chemistry, , vol. 28, # 6 p. 714 - 717 2,3,5,6-tetrahy... CAS#:20463-30-3 pilsicainide CAS#:88069-67-4 Literature: Journal of Medicinal Chemistry, , vol. 28, # 6 p. 714 - 717 Precursor & DownStream Precursor 5 CAS#:20463-30-3 2,3,5,6-tetrahy... CAS#:94794-30-6 pyrrolizidine-7... CAS#:88069-56-1 Tetrahydro-1H-p... CAS#:87-62-7 2,6-xylidine DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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