| Chemical & Physical Properties | |
|---|---|
| CAS Number | 21416-53-5 |
| Catalog No. | 2A-9012014 |
| Chinese Name | 苦亭 |
| Synonyms | picrotoxin component 2; (-)-Picrotin |
| Molecular Formula | C15H18O7 |
| Molecular Weight | 310.30 |
| Purity | 98 |
| Density | 1.59g/cm3 |
| Boiling Point | 595.8ºC at 760 mmHg |
| Melting Point | 256-258ºC |
| Storage Condition | -20°C, sealed, dry |
| Application | Picrotin is an inhibitor of glycine receptors (GlyRs), inhibiting α2 GlyR, α1 GlyR and α3 GlyR. |
| PubChem ID | 329831464 |
| MDL Number | MFCD00148946 |
| SMILES | CC(C)(O)C1C2OC(=O)C1C3(O)CC4OC45C(=O)OC2C35C |
| InChI | 1S/C15H18O7/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9/h5-9,18-19H,4H2,1-3H3 |
| InChI Key | RYEFFICCPKWYML-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/12014_1_21416_53_5.pdf |
| Bioactivity | Picrotin is an inhibitor of glycine receptors (GlyRs) which blocks α2 GlyR, α1 GlyR and α3 GlyR[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Target α2 GlyR, α1 GlyR, α3 GlyR[1][2] References [1]. Li P, et al. Gating effects on picrotin block of glycine receptors. Neuroreport. 2012 Dec 5;23(17):1017-20. [2]. Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9. Chemical & Physical Properties Density 1.59g/cm3 Boiling Point 595.8ºC at 760 mmHg Melting Point 256-258ºC Molecular Formula C15H18O7 Molecular Weight 310.29900 Flash Point 228.9ºC Exact Mass 310.10500 PSA 105.59000 Vapour Pressure 1.12E-16mmHg at 25°C Index of Refraction 1.637 InChIKey RYEFFICCPKWYML-QCGISDTRSA-N SMILES CC(C)(O)C1C2OC(=O)C1C1(O)CC3OC34C(=O)OC2C14C |
| Use of | Picrotin is an inhibitor of glycine receptors (GlyRs) which blocks α2 GlyR, α1 GlyR and α3 GlyR[1][2]. Properties Name picrotin Synonym More Synonyms Picrotin Biological Activity Description Picrotin is an inhibitor of glycine receptors (GlyRs) which blocks α2 GlyR, α1 GlyR and α3 GlyR[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease α2 GlyR, α1 GlyR, α3 GlyR[1][2] References [1]. Li P, et al. Gating effects on picrotin block of glycine receptors. Neuroreport. 2012 Dec 5;23(17):1017-20. [2]. Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9. Chemical & Physical Properties Molecular Formula C15H18O7 Exact Mass 310.10500 PSA 105.59000 Index of Refraction 1.637 InChIKey RYEFFICCPKWYML-QCGISDTRSA-N |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Picloxydine | 5636-92-0 | 2A-9012008 |
| Picodralazine | 17692-43-2 | 2A-9012009 |
| Picotamide | 32828-81-2 | 2A-9012010 |
| picotrin | 64063-57-6 | 2A-9012011 |
| Picroside | 2A-303096 | 2A-9012012 |
| Pidobenzone | 138506-45-3 | 2A-9012015 |
| Pidotimod | 121808-62-6 | 2A-9012016 |
| Pikamilone sodium salt | 62936-56-5 | 2A-9012017 |
| Pildralazine | 56393-22-7 | 2A-9012018 |
| Pilsicainide | 88069-67-4 | 2A-9012019 |
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