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Peruvoside structure, CAS 1182-87-2

Peruvoside

CAS Number1182-87-2

SynonymsCannogenin thevetoside; Encordin; Peruvosid; peruvoside; EINECS 214-659-9; MFCD00133752; Peruvoside from Thevetia neriifolia; Cannogenin |A-L-Thevetoside

Molecular FormulaC30H44O9

Molecular Weight548.67

Purity98%

Density1.31g/cm3

Boiling Point731.6ºC at 760 mmHg

Melting Point161-164ºC

Flash Point

Appearance

EINECS

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Cat. No.: 2A-9011946 Purity: 98%
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Quality Control of [ 1182-87-2 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1182-87-2
Catalog No.2A-9011946
Chinese Name黄夹次苷
SynonymsCannogenin thevetoside; Encordin; Peruvosid; peruvoside; EINECS 214-659-9; MFCD00133752; Peruvoside from Thevetia neriifolia; Cannogenin |A-L-Thevetoside
Molecular FormulaC30H44O9
Molecular Weight548.67
Purity98
Density1.31g/cm3
Boiling Point731.6ºC at 760 mmHg
Melting Point161-164ºC
Storage Condition2-8°C
ApplicationPeruvoside is a potent inhibitor of Src, PI3K, JNK, STAT, and EGFR. Peruvoside induces apoptosis and autophagy and has broad-spectrum anti-tumor activity in breast cancer, lung cancer, liver cancer an
MDL NumberC30H44O9
SMILESCOC1C(O)C(C)OC(OC2CCC3(C=O)C(CCC4C3CCC3(C)C(C5=CC(=O)OC5)CCC43O)C2)C1O
InChIInChI=1S/C30H44O9/c1-16-24(33)26(36-3)25(34)27(38-16)39-19-6-10-29(15-31)18(13-19)4-5-22-21(29)7-9-28(2)20(8-11-30(22,28)35)17-12-23(32)37-14-17/h12,15-16,18-22,24-27,33-35H,4-11,13-14H2,1-3H3/t16?,18-,19+,20-,21?,22?,24-,25?,26?,27-,28-,29-,30+/m1/s1
InChI KeyPMTSPAGBAFCORP-HBUONDEYSA-N
Hazard SymbolsTransport
MSDSmsds/11946_1_1182_87_2.pdf
BioactivityPeruvoside is a potent inhibitor of Src, PI3K, JNK, STAT, and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib[1][2][3][4]. Related Catalog Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> MAPK/ERK Pathway >> JNK References [1]. Lai Y, et al. Peruvoside is a novel Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways. Am J Cancer Res. 2022 Jun 15;12(6):2576-2593. [2]. Reddy D, et al. Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers. Life Sci. 2020 Jan 15;241:117147. doi: 10.1016/j.lfs.2019.117147. Epub 2019 Dec 9. PMID: 31830480. [3]. Feng Q, et al. Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death. Molecules. 2016 Apr 22;21(4):534. [4]. Wu KX, et al. The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses. Acta Pharm Sin B. 2023 May;13(5):2039-2055. Chemical & Physical Properties Density 1.31g/cm3 Boiling Point 731.6ºC at 760 mmHg Melting Point 161-164ºC Molecular Formula C30H44O9 Molecular Weight 548.66 Flash Point 236.2ºC Exact Mass 548.29900 PSA 131.75000 LogP 2.28920 Vapour Pressure 1.04E-24mmHg at 25°C Index of Refraction 1.588 InChIKey PMTSPAGBAFCORP-HBUONDEYSA-N SMILES COC1C(O)C(C)OC(OC2CCC3(C=O)C(CCC4C3CCC3(C)C(C5=CC(=O)OC5)CCC43O)C2)C1O
Use ofProperties Name (3S,5R,8R,9S,10R,13R,14S,17R)-3-[(2R,3S,4R,5S,6S)-3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-14-hydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-10-carbaldehyde Synonym More Synonyms peruvoside Biological Activity Related Catalog Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> MAPK/ERK Pathway >> JNK References [1]. Lai Y, et al. Peruvoside is a novel Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways. Am J Cancer Res. 2022 Jun 15;12(6):2576-2593. [3]. Feng Q, et al. Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death. Molecules. 2016 Apr 22;21(4):534. [4]. Wu KX, et al. The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses. Acta Pharm Sin B. 2023 May;13(5):2039-2055. Chemical & Physical Properties Molecular Formula C30H44O9 Exact Mass 548.29900 PSA 131.75000 LogP 2.28920 Index of Refraction 1.588 InChIKey PMTSPAGBAFCORP-HBUONDEYSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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