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Perphenazine structure, CAS 58-39-9

Perphenazine

CAS Number58-39-9

Synonyms2-{4-[3-(2-Chlor-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol; 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol; 2-(4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol; 2-{4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl}ethanol; EINECS 200-381-5; Chlorpiprozine; 1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine; 2-Chloro-10-[3-[1-(2-hydroxyethyl)-4-piperazinyl]propyl]phenothiazine; 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol; 2-{4-[3-(2-chloro-10H-phénothiazin-10-yl)propyl]pipérazin-1-yl}éthanol; Trilafon; MFCD00056798; 2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine; PZC; g-[4-(b-Hydroxyethyl)piperazin-1-yl]propyl-2-chlorophenothiazine; 2-{4-[3-(2-Chloro-phenothiazin-1

Molecular FormulaC21H26ClN3OS

Molecular Weight403.97

Purity98%

Density1.3±0.1 g/cm3

Boiling Point580.4±50.0 °C at 760 mmHg

Melting Point35339ºC

Flash Point

Appearancepowder

EINECS200-381-5

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9011943 Purity: 98%
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Quality Control of [ 58-39-9 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number58-39-9
Catalog No.2A-9011943
Chinese Name奋乃静
Synonyms2-{4-[3-(2-Chlor-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol; 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol; 2-(4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol; 2-{4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl}ethanol; EINECS 200-381-5; Chlorpiprozine; 1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine; 2-Chloro-10-[3-[1-(2-hydroxyethyl)-4-piperazinyl]propyl]phenothiazine; 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol; 2-{4-[3-(2-chloro-10H-phénothiazin-10-yl)propyl]pipérazin-1-yl}éthanol; Trilafon; MFCD00056798; 2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine; PZC; g-[4-(b-Hydroxyethyl)piperazin-1-yl]propyl-2-chlorophenothiazine; 2-{4-[3-(2-Chloro-phenothiazin-1
Molecular FormulaC21H26ClN3OS
Molecular Weight403.97
Purity98
Density1.3±0.1 g/cm3
Boiling Point580.4±50.0 °C at 760 mmHg
Melting Point35339ºC
Appearancepowder
Water SolubilityWater solubility: insoluble; water solubility: 28.
Storage ConditionThe warehouse is low-temperature, ventilated, dry,
ApplicationPerphenazine is a classic antipsychotic drug that can inhibit 5-HT2A receptors, α1A adrenergic receptors, dopamine D2/D3, D2L receptors, and histamine H1 receptors, with corresponding Ki values ​​of 5
EINECS200-381-5
HTC2934999090
PubChem ID24278642
MDL NumberMFCD00056798
SMILESClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
InChI1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChI KeyRGCVKNLCSQQDEP-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard SymbolsTransport
MSDSmsds/11943_1_58_39_9.pdf
BioactivityPerphenazine is a typical antipsychotic drug, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Target 5-HT2A Receptor:5.6 nM (Ki) H1 receptor:8 nM (Ki) α1A adrenergic receptor:10 nM (Ki) D2 receptor:0.765 nM (Ki) D3 receptor:0.13 nM (Ki) D2L receptor:3.4 nM (Ki) References [1]. Richtand NM, et al. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology. 2007 Aug;32(8):1715-26. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 580.4±50.0 °C at 760 mmHg Melting Point 35339ºC Molecular Formula C21H26ClN3OS Molecular Weight 403.969 Flash Point 304.8±30.1 °C Exact Mass 403.148499 PSA 55.25000 LogP 4.34 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.627 InChIKey RGCVKNLCSQQDEP-UHFFFAOYSA-N SMILES OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
Use ofProperties Articles44 Name perphenazine Synonym More Synonyms Perphenazine Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease 5-HT2A Receptor:5.6 nM (Ki) H1 receptor:8 nM (Ki) α1A adrenergic receptor:10 nM (Ki) D2 receptor:0.765 nM (Ki) D3 receptor:0.13 nM (Ki) References [1]. Richtand NM, et al. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology. 2007 Aug;32(8):1715-26. Chemical & Physical Properties Exact Mass 403.148499 PSA 55.25000 Index of Refraction 1.627 InChIKey RGCVKNLCSQQDEP-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 97.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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