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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 2-AMINO-N-(1,2-DIPHENYLPROPAN-2-YL)ACETAMIDE HYDROCHLORIDE
2-AMINO-N-(1,2-DIPHENYLPROPAN-2-YL)ACETAMIDE HYDROCHLORIDE structure, CAS 111686-79-4

2-AMINO-N-(1,2-DIPHENYLPROPAN-2-YL)ACETAMIDE HYDROCHLORIDE

CAS Number111686-79-4

SynonymsPR 934-423A; Remacemide HCl; Remacemide hydrochloride; REMACEMIDE HYDROCHLORIDE

Molecular FormulaC17H21ClN2O

Molecular Weight304.81

Purity96+%

Density

Boiling Point466.4ºC at 760mmHg

Melting Point

Flash Point

Appearancesolid

EINECS0

MSDSChineseEnglish

Symboltransportation

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Cat. No.: 2A-0201737 Purity: 96+%
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Quality Control of [ 111686-79-4 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number111686-79-4
Catalog No.2A-0201737
Chinese Name盐酸瑞马酰胺
SynonymsPR 934-423A; Remacemide HCl; Remacemide hydrochloride; REMACEMIDE HYDROCHLORIDE
Molecular FormulaC17H21ClN2O
Molecular Weight304.81
Purity96+
Boiling Point466.4ºC at 760mmHg
Appearancesolid
Storage Conditionroom temperature
ApplicationRemacemide hydrochloride (FPL 12924AA) is a moderately potent inhibitor of sodium channels and a weak, noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, with an IC50 of 68 μM for
EINECS0
HTC2924299090
UN(IATA)0
PubChem ID329825340
MDL NumberMFCD00882179
SMILESCC(Cc1ccccc1)(NC(=O)CN)c1ccccc1.Cl
InChIInChI=1S/C17H20N2O.ClH/c1-17(19-16(20)13-18,15-10-6-3-7-11-15)12-14-8-4-2-5-9-14;/h2-11H,12-13,18H2,1H3,(H,19,20);1H
InChI KeyHYQMIUSWZXGTCC-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbolstransportation
BioactivityRemacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively[1]. Remacemide hydrochloride is an anticonvulsant agent[2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Target IC50: 68-76 μM (NMDA receptor)[1] IC50:160.6 μM(sodium channel)[2] In Vitro Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM[2]. In Vivo Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats[3]. Animal Model: Female Sprague-Dawley rats ( 190-210 g )[3] Dosage: 100 mg/kg and 150 mg/kg Administration: Orogastric gavage; once a day; 7 days Result: Increased the number of sessions required to complete audio/visual discrimination (AVD) training. References [1]. G C Palmer, et al. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248. [2]. Sarah Santangeli, et al. Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8. [3]. L K M Wright, et al. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicol Teratol. May-Jun 2007;29(3):348-59. Chemical & Physical Properties Boiling Point 466.4ºC at 760mmHg Molecular Formula C17H21ClN2O Molecular Weight 304.81400 Flash Point 235.9ºC Exact Mass 304.13400 PSA 55.12000 LogP 4.11260 Vapour Pressure 7.09E-09mmHg at 25°C InChIKey HYQMIUSWZXGTCC-UHFFFAOYSA-N SMILES CC(Cc1ccccc1)(NC(=O)CN)c1ccccc1.Cl
Use ofRemacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively[1]. Remacemide hydrochloride is an anticonvulsant agent[2]. Properties Articles26 Name 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide,hydrochloride Synonym More Synonyms Remacemide hydrochloride Biological Activity Description Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively[1]. Remacemide hydrochloride is an anticonvulsant agent[2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR IC50: 68-76 μM (NMDA receptor)[1] IC50:160.6 μM(sodium channel)[2] In Vitro Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM[2]. References [1]. G C Palmer, et al. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248. [2]. Sarah Santangeli, et al. Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8. [3]. L K M Wright, et al. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicol Teratol. May-Jun 2007;29(3):348-59. Chemical & Physical Properties Exact Mass 304.13400 PSA 55.12000 LogP 4.11260 InChIKey HYQMIUSWZXGTCC-UHFFFAOYSA-N
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Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 United Nations shipping name European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Remacemide hydrochloride) IMDG Code: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Remacemide hydrochloride) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (Remacemide hydrochloride) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations International Air Transport Dangerous Regulations: Yes Marine Pollutants (Yes/No): Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3),
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