CAS Number2058-46-0
Synonymsengemycin; mepatar; Oxytetracycline Hydrochloride; MFCD00135815; oxytetracyclin hydrochloride; oxlopar; EINECS 218-161-2; oxytetracycline HCl; Oxycline; terramycin hydrochloride; otetryn; TOXINAL; GEOMYCIN; tm5; OTC
Molecular FormulaC22H25ClN2O9
Molecular Weight496.89
Purity98%
Density1.71 g/cm3
Boiling Point839.6ºC at 760 mmHg
Melting Point180°C
AppearanceYellow crystalline solid
EINECS218-161-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2058-46-0 |
| Catalog No. | 2A-9011845 |
| Chinese Name | 盐酸土霉素 |
| Synonyms | engemycin; mepatar; Oxytetracycline Hydrochloride; MFCD00135815; oxytetracyclin hydrochloride; oxlopar; EINECS 218-161-2; oxytetracycline HCl; Oxycline; terramycin hydrochloride; otetryn; TOXINAL; GEOMYCIN; tm5; OTC |
| Molecular Formula | C22H25ClN2O9 |
| Molecular Weight | 496.89 |
| Purity | 98 |
| Density | 1.71 g/cm3 |
| Boiling Point | 839.6ºC at 760 mmHg |
| Melting Point | 180°C |
| Appearance | Yellow crystalline solid |
| Water Solubility | >100 g/L |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Application | Oxytetracycline hydrochloride is an antibiotic that belongs to the tetracycline class. Oxytetracycline hydrochloride potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydroch |
| EINECS | 218-161-2 |
| HTC | 3003209000 |
| PubChem ID | 329757217 |
| MDL Number | MFCD00135815 |
| SMILES | Cl.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O |
| InChI | 1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1 |
| InChI Key | UBDNTYUBJLXUNN-IFLJXUKPSA-N |
| Beilstein/REAXYS | 3853107 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/11845_1_2058_46_0.pdf |
| Bioactivity | Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity[1][2][3]. Related Catalog Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial Target Gram-negative and Gram-positive bacteria[1] HSV-1[3] In Vitro Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes[2]. In Vivo The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter[1]. For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days[1]. References [1]. Elia AC, et al. Transferability of oxytetracycline (OTC) from feed to carp muscle and evaluation of the antibiotic effects on antioxidant systems in liver and kidney. Fish Physiol Biochem. 2014 Aug;40(4):1055-68. [2]. Pickens LB, et al. Oxytetracycline biosynthesis. J Biol Chem. 2010 Sep 3;285(36):27509-15. [3]. Oguz Guvenmez, et al. A New Treatment Method for Herpes Simplex Virus Type 1-related Skin Lesions. Scientific & Academic. 2019; 8(1): 6-8. Chemical & Physical Properties Density 1.71 g/cm3 Boiling Point 839.6ºC at 760 mmHg Melting Point 180°C Molecular Formula C22H25ClN2O9 Molecular Weight 533.356 Flash Point 461.6ºC Exact Mass 532.101563 PSA 201.85000 LogP 0.25870 Vapour Pressure 2.17E-30mmHg at 25°C Storage condition 0-6°C Water Solubility >100 g/L |
| Use of | Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity[1][2][3]. Properties Articles49 Name oxytetracycline hydrochloride Synonym More Synonyms Oxytetracycline HCl Biological Activity Description Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity[1][2][3]. Related Catalog Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial Gram-negative and Gram-positive bacteria[1] HSV-1[3] In Vitro Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes[2]. References [1]. Elia AC, et al. Transferability of oxytetracycline (OTC) from feed to carp muscle and evaluation of the antibiotic effects on antioxidant systems in liver and kidney. Fish Physiol Biochem. 2014 Aug;40(4):1055-68. [2]. Pickens LB, et al. Oxytetracycline biosynthesis. J Biol Chem. 2010 Sep 3;285(36):27509-15. [3]. Oguz Guvenmez, et al. A New Treatment Method for Herpes Simplex Virus Type 1-related Skin Lesions. Scientific & Academic. 2019; 8(1): 6-8. Chemical & Physical Properties Exact Mass 532.101563 PSA 201.85000 LogP 0.25870 |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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