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Neomycin sulfate structure, CAS 1405-10-3

Neomycin sulfate

CAS Number1405-10-3

SynonymsNeomycin Sulfate; FradioMycin Sulfate; Neomycin Sulphate; Neomycin trisulfate salt hydrate; EINECS 215-773-1; MFCD00037007

Molecular FormulaC23H52N6O25S3

Molecular Weight908.88 (anhydrous basis)

Purity98%

Density

Boiling Point1046.1ºC at 760 mmHg

Melting Point>187°C (dec.)

Flash Point

Appearancepowder

EINECS215-773-1

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9011610 Purity: 98%
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Quality Control of [ 1405-10-3 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1405-10-3
Catalog No.2A-9011610
Chinese Name硫酸新霉素
SynonymsNeomycin Sulfate; FradioMycin Sulfate; Neomycin Sulphate; Neomycin trisulfate salt hydrate; EINECS 215-773-1; MFCD00037007
Molecular FormulaC23H52N6O25S3
Molecular Weight908.88 (anhydrous basis)
Purity98
Boiling Point1046.1ºC at 760 mmHg
Melting Point>187°C (dec.)
Appearancepowder
Water SolubilityH2O: 50 mg/mL As a stock solution. Stock solutions
Storage ConditionKeep the receptacle sealed, stored in a cool, dry
ApplicationNeomycin sulfate is an aminoglycoside antibiotic used to prevent or treat bacterial infections.
EINECS215-773-1
HTC2941909000
PubChem ID57654443
SMILESO.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)C(N)[C@@H](O)[C@@H]1O
InChI1S/C23H46N6O13.3H2O4S.H2O/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4;/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4);1H2/t5-,6+,7-,8+,9-,10-,11?,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;;;;/m1..../s1
InChI KeyWHAGUNPVKDUVFV-QGTTWHFQSA-N
NACRES CodeNA.85
UNSPSC51101500
Hazard SymbolsTransport
MSDSmsds/11610_1_1405_10_3.pdf
BioactivityNeomycin sulfate is an aminoglycoside antibiotic used for preventing or treating bacterial infections. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Infection In Vitro Neomycin inhibits thrombin-stimulated release of inositol 1,4,5-trisphosphate (IP3), by selectively binding PIP2, but does not inhibit 32P incorporation into PI or initiation of DNA synthesis[1]. Neomycin (10 μM-1 mM) induces considerable release of [3H]arachidonic acid from phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine in saponin-permeabilized human platelets prelabeled with [3H]arachidonic acid. Moreover, neomycin enhances arachidonic acid release induced by thrombin. Addition of neomycin (100 μM) to 45Ca2+-preloaded platelets elicits 45Ca2+ mobilizatioin from intracellular stores[2]. Neomycin (0-10 mM) inhibits guanosine 5'-[gamma-thio]triphosphate-stimulated PLD activity in digitonin-permeabilized NG108-15 cells in a concentration-dependent manner (50% inhibition at 100 μM). Neomycin similarly inhibits PLD activity present in rat brain membranes and assayed in vitro with [3H]phosphatidylcholine as substrate (50% inhibition at 65 μM)[3]. Neomycin (5 mM) causes reversible reductions in the level of intracellular Ca2+, but PtdIns(4,5)P2 is not required for the channel activity[4]. References [1]. Carney, D.H., et al. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. Cell, 1985. 42(2): p. 479-88. [2]. Nakashima, S., et al. Neomycin is a potent agent for arachidonic acid release in human platelets. Biochem Biophys Res Commun, 1987. 146(2): p. 820-6. [3]. Liscovitch, M., et al., Inhibition of neural phospholipase D activity by aminoglycoside antibiotics. Biochem J, 1991. 279 ( Pt 1): p. 319-21. [4]. Huang K, et al. CRAC channel is inhibited by neomycin in a Ptdlns(4,5)P2-independent manner. Cell Biochem Funct. 2015 Mar;33(2):97-100. Chemical & Physical Properties Boiling Point 1046.1ºC at 760 mmHg Melting Point >187°C (dec.) Molecular Formula C23H52N6O25S3 Molecular Weight 908.88 Flash Point 586.5ºC PSA 436.09000 Vapour Pressure 0mmHg at 25°C Index of Refraction 56 ° (C=10, H2O) InChIKey KWBUARAINLGYMG-BNAHOEIWSA-N SMILES NCC1OC(OC2C(CO)OC(OC3C(O)C(N)CC(N)C3OC3OC(CN)C(O)C(O)C3N)C2O)C(N)C(O)C1O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O Storage condition 2-8°C Stability Stable. Incompatible with strong oxidizing agents. Water Solubility H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.
Use ofNeomycin sulfate is an aminoglycoside antibiotic used for preventing or treating bacterial infections. Properties Articles48 Name Fradiomycin Sulfate Synonym More Synonyms Neomycin sulfate Biological Activity Description Neomycin sulfate is an aminoglycoside antibiotic used for preventing or treating bacterial infections. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Infection References [1]. Carney, D.H., et al. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. Cell, 1985. 42(2): p. 479-88. [2]. Nakashima, S., et al. Neomycin is a potent agent for arachidonic acid release in human platelets. Biochem Biophys Res Commun, 1987. 146(2): p. 820-6. [3]. Liscovitch, M., et al., Inhibition of neural phospholipase D activity by aminoglycoside antibiotics. Biochem J, 1991. 279 ( Pt 1): p. 319-21. [4]. Huang K, et al. CRAC channel is inhibited by neomycin in a Ptdlns(4,5)P2-independent manner. Cell Biochem Funct. 2015 Mar;33(2):97-100. Chemical & Physical Properties Molecular Formula C23H52N6O25S3 PSA 436.09000 InChIKey KWBUARAINLGYMG-BNAHOEIWSA-N Stability Stable. Incompatible with strong oxidizing agents.
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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