CAS Number13669-70-0
Synonyms5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine; Sinalgico; EINECS 237-148-2; 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride; 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine; Ajan; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine; Nefopam; MFCD00056181; Acupan
Molecular FormulaC17H19NO
Molecular Weight289.80
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point369.5±37.0 °C at 760 mmHg
Melting Point260 °C (dec.) (lit.)
Appearancepowder
EINECS245-585-5
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 13669-70-0 |
| Catalog No. | 2A-9011601 |
| Chinese Name | 奈福泮 |
| Synonyms | 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine; Sinalgico; EINECS 237-148-2; 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride; 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine; Ajan; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine; Nefopam; MFCD00056181; Acupan |
| Molecular Formula | C17H19NO |
| Molecular Weight | 289.80 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 369.5±37.0 °C at 760 mmHg |
| Melting Point | 260 °C (dec.) (lit.) |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Nefopam (phenazocine) is an orally active, non-opioid and non-steroidal central analgesic. Nefopam blocks voltage-sensitive sodium channels (IC50=27µM) and modulates glutamatergic transmission in rode |
| EINECS | 245-585-5 |
| HTC | 2933990090 |
| PubChem ID | 329825616 |
| MDL Number | MFCD00012750 |
| SMILES | Cl.CN1CCOC(c2ccccc2)c3ccccc3C1 |
| InChI | 1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H |
| InChI Key | CNNVSINJDJNHQK-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/11601_1_13669_70_0.pdf |
| Use of | Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 µM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups[1][2][3]. Properties Name 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Synonym More Synonyms Nefopam Biological Activity Description Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 µM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups[1][2][3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Chemical & Physical Properties Molecular Formula C17H19NO Exact Mass 253.146667 PSA 12.47000 Index of Refraction 1.564 InChIKey RGPDEAGGEXEMMM-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1H-2,5-Benzoxazocine, 3,4,5,6,7-tetrahydro-5-methyl-1-phenyl- CAS REGISTRY NUMBER : 13669-70-0 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C17-H19-N-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Cardiac - change in rate REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 283,1508,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - excitement Cardiac - pulse rate increase, without fall in BP REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 283,1508,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4198424 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) REFERENCE : DDEVD6 Drug Development and Evaluation. (Gustav Fischer Verlag, Postfach 720143, D-7000 Stuttgart 70, Fed. Rep. Ger.) V.1- 1977- Volume(issue)/page/year: 3,10,1979 Safety Information HS Code 2933990090 Synthetic Route Nefopam hydroch... CAS#:23327-57-3 CAS#:13669-70-0 CAS#:17494-19-8 CAS#:13669-70-0 Literature: Australian Journal of Chemistry, , vol. 35, # 11 p. 2307 - 2314 2-(1-PHENYL-2,3... CAS#:18409-76-2 CAS#:13669-70-0 Literature: Australian Journal of Chemistry, , vol. 35, # 11 p. 2307 - 2314 Precursor & DownStream Precursor 3 CAS#:23327-57-3 Nefopam hydroch... CAS#:18409-76-2 2-(1-PHENYL-2,3... CAS#:84940-28-3 1-PHENYL-3,4,5,... DownStream 1 CAS#:865-50-9 Iodomethane-d3 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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