CAS Number42924-53-8
Synonyms4-(6-méthoxynaphtalén-2-yl)butan-2-one; Mebutan; Relifen; 4-(6-Methoxy-2-naphthyl)-butan-2-one; Arthaxan; Relif; 4-(6-Methoxynaphthalen-2-yl)butan-2-on; 4-(6-methoxynaphthalen-2-yl)butan-2-one; Nabumetona; 4-(6-Methoxy-2-naphthyl)butan-2-one; MFCD00079518; Nabumetone; Relafen; Listran; Nabuser; Relifex; Dolsinal; 4-(6-Methoxy-2-naphthyl)-2-butanone
Molecular FormulaC15H16O2
Molecular Weight228.29
Purity98%
Density1.1±0.1 g/cm3
Boiling Point371.1±17.0 °C at 760 mmHg
Melting Point80-81ºC
AppearanceWhite/almost white, crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 42924-53-8 |
| Catalog No. | 2A-9011542 |
| Chinese Name | 萘丁美酮 |
| Synonyms | 4-(6-méthoxynaphtalén-2-yl)butan-2-one; Mebutan; Relifen; 4-(6-Methoxy-2-naphthyl)-butan-2-one; Arthaxan; Relif; 4-(6-Methoxynaphthalen-2-yl)butan-2-on; 4-(6-methoxynaphthalen-2-yl)butan-2-one; Nabumetona; 4-(6-Methoxy-2-naphthyl)butan-2-one; MFCD00079518; Nabumetone; Relafen; Listran; Nabuser; Relifex; Dolsinal; 4-(6-Methoxy-2-naphthyl)-2-butanone |
| Molecular Formula | C15H16O2 |
| Molecular Weight | 228.29 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 371.1±17.0 °C at 760 mmHg |
| Melting Point | 80-81ºC |
| Appearance | White/almost white, crystalline powder |
| Storage Condition | Refrigerator |
| Application | Nabumetone is an orally available non-acid anti-inflammatory agent, a potent and selective COX-2 inhibitor, and the precursor of the active metabolite 6MNA. |
| HTC | 2914399090 |
| MDL Number | MFCD00079518 |
| SMILES | COc1ccc2cc(CCC(C)=O)ccc2c1 |
| InChI | 1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3 |
| InChI Key | BLXXJMDCKKHMKV-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/11542_1_42924_53_8.pdf |
| Bioactivity | Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA. Related Catalog Research Areas >> Inflammation/Immunology Target COX-2 In Vitro Nabumetone is a potent and selective COX-2 inhibitor. Nabumetone (50 μmol-2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression[1]. In Vivo Nabumetone (79 mg/kg, p.o.) inhibits paw oedema and paw exudate PGE2 in rats. Nabumetone does not induce gastric damage and causes only 57% inhibition of gastric mucosal 6-keto-PGF1α production in rats[2]. Nabumetone (25, 50, 100 mg/kg, i.p.) dose-dependently inhibits the increase of DDC-induced mucus secretion and stimulates stress-induced mucus secretion in rats. Nabumetone (25 mg/kg, i.p.) significantly suppresses stress-induced ulcer index in rats[3]. Cell Assay Every cell line is plated into 6-well plates at a concentration of 3 × 105/mL with or without drugs (Nabumetone, etc.) and incubated for 48 h. Viable cells are then counted using the trypan blue dye exclusion test. The percentage of proliferation inhibition is calculated as 1-(viable cells exposed to drug/viable cells in control) ×100[1]. Animal Admin Rats[3] Albino male rats (250- to 300-g body weight) are used in the study. The animals are maintained in a single cage and are deprived of food for 16 h before the onset of experiments. Free access to water is allowed until 1 h before the beginning of experiments. There are eight rats in each group. The animals are pretreated with intraperitoneal injections of Nabumetone or dipyrone at 25-, 50-, or 100-mg/kg doses for 3 days[3]. References [1]. Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46(5):753-6. [2]. Melarange R, et al. Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid): comparison with indomethacin. Agents Actions. 1992;Spec No:C82-3. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 371.1±17.0 °C at 760 mmHg Melting Point 80-81ºC Molecular Formula C15H16O2 Molecular Weight 228.286 Flash Point 165.4±14.5 °C Exact Mass 228.115036 PSA 26.30000 LogP 2.82 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.576 InChIKey BLXXJMDCKKHMKV-UHFFFAOYSA-N SMILES COc1ccc2cc(CCC(C)=O)ccc2c1 Storage condition Refrigerator |
| Use of | Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA. Properties Articles43 Name nabumetone Synonym More Synonyms Nabumetone Biological Activity Description Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA. Related Catalog Research Areas >> Inflammation/Immunology Animal Admin Rats[3] Albino male rats (250- to 300-g body weight) are used in the study. The animals are maintained in a single cage and are deprived of food for 16 h before the onset of experiments. Free access to water is allowed until 1 h before the beginning of experiments. There are eight rats in each group. The animals are pretreated with intraperitoneal injections of Nabumetone or dipyrone at 25-, 50-, or 100-mg/kg doses for 3 days[3]. References [1]. Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46(5):753-6. [2]. Melarange R, et al. Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid): comparison with indomethacin. Agents Actions. 1992;Spec No:C82-3. Chemical & Physical Properties Molecular Formula C15H16O2 Exact Mass 228.115036 PSA 26.30000 Index of Refraction 1.576 InChIKey BLXXJMDCKKHMKV-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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