CAS Number175135-47-4
Synonyms2-[4-[(4-Methoxyphenyl)methoxy]phenyl]-acetonitrile; 4-(4-methoxybenzyloxy)benzylnitrile; {4-[(4-Methoxybenzyl)oxy]phenyl}acetonitrile; O4I1; 2-(4-((4-Methoxybenzyl)oxy)phenyl)acetonitrile; 2-(4-[(4-METHOXYBENZYL)OXY]PHENYL)ACETONITRILE; O4I-1
Molecular FormulaC16H15O2N1
Molecular Weight253.3
Purity96+%
Density1.1±0.1 g/cm3
Boiling Point424.5±30.0 °C at 760 mmHg
Melting Point140ºC
Appearancelight yellow solid
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 175135-47-4 |
| Catalog No. | 2A-0114910 |
| Chinese Name | O4I1 |
| Synonyms | 2-[4-[(4-Methoxyphenyl)methoxy]phenyl]-acetonitrile; 4-(4-methoxybenzyloxy)benzylnitrile; {4-[(4-Methoxybenzyl)oxy]phenyl}acetonitrile; O4I1; 2-(4-((4-Methoxybenzyl)oxy)phenyl)acetonitrile; 2-(4-[(4-METHOXYBENZYL)OXY]PHENYL)ACETONITRILE; O4I-1 |
| Molecular Formula | C16H15O2N1 |
| Molecular Weight | 253.3 |
| Purity | 96+ |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 424.5±30.0 °C at 760 mmHg |
| Melting Point | 140ºC |
| Appearance | light yellow solid |
| Storage Condition | -20℃ |
| Application | O4I1 is a potent Oct3/4 inducer. |
| EINECS | 0 |
| HTC | 2926909090 |
| UN(IATA) | 0 |
| MDL Number | MFCD00067778 |
| SMILES | COc1ccc(COc2ccc(CC#N)cc2)cc1 |
| InChI Key | QJEJLARVLKHYFW-UHFFFAOYSA-N |
| Bioactivity | O4I1 is as a potent Oct3/4 inducer.Target: Oct3/4O4I1 enhances Oct3/4 gene expression, increases Oct3/4 protein levels, and promotes Oct3/4 mediated transcriptional activation. O4I1 activates Oct3/4 at the transcriptional and translational levels in diverse human cell lines. O4I1 promotes Oct3/4 expression in untransfected HEK293 cells quantified by qRT-PCR after 72 h of treatment. O4I1 is sufficient to enhance Oct3/4 overexpression 2-fold and 3-fold after 48 and 72 h of treatment, respectively. Related Catalog Signaling Pathways >> Stem Cell/Wnt >> Oct3/4 Research Areas >> Others References [1]. Cheng X, et al. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J Med Chem. 2015 Jun 25;58(12):4976-4983. [2]. Mrowka, et al. Method for activating OCT4 for induction of pluripotent stem cell formation. From PCT Int. Appl. (2014), WO 2014000814 A1 20140103. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 424.5±30.0 °C at 760 mmHg Melting Point 140ºC Molecular Formula C16H15NO2 Molecular Weight 253.296 Flash Point 154.8±17.8 °C Exact Mass 253.110275 PSA 42.25000 LogP 2.93 Appearance of Characters light yellow solid Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.570 InChIKey QJEJLARVLKHYFW-UHFFFAOYSA-N SMILES COc1ccc(COc2ccc(CC#N)cc2)cc1 Storage condition -20℃ |
| Use of | Properties Name 2-[4-[(4-methoxyphenyl)methoxy]phenyl]acetonitrile Synonym More Synonyms O4I1 Biological Activity Related Catalog Research Areas >> Others References [2]. Mrowka, et al. Method for activating OCT4 for induction of pluripotent stem cell formation. From PCT Int. Appl. (2014), WO 2014000814 A1 20140103. Chemical & Physical Properties Molecular Formula C16H15NO2 Exact Mass 253.110275 PSA 42.25000 Appearance of Characters light yellow solid Index of Refraction 1.570 InChIKey QJEJLARVLKHYFW-UHFFFAOYSA-N Storage condition -20℃ |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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