CAS Number54-36-4
SynonymsChlorisondamine diiodide; Mepyrapone; Metyrapone; Methopirapone; Metroprione; Methapyrapone; Metyrapon; Methopyrinine; Methopyrone; 2-methyl-1,2-dipyridin-3-ylpropan-1-one; 2-Methyl-1,2-di(pyridin-3-yl)propan-1-one; Methopyrapone; 2-Methyl-1,2-di(3-pyridinyl)-1-propanone; 2-méthyl-1,2-dipyridin-3-ylpropan-1-one; 2-Methyl-1,2-dipyridin-3-ylpropan-1-on
Molecular FormulaC14H14N2O
Molecular Weight226.27
Purity96%
Density1.1±0.1 g/cm3
Boiling Point384.4±22.0 °C at 760 mmHg
Melting Point52-55 °C (lit.)
Appearancepowder
EINECS200-206-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54-36-4 |
| Catalog No. | 2A-9011425 |
| Chinese Name | 美替拉酮 |
| Synonyms | Chlorisondamine diiodide; Mepyrapone; Metyrapone; Methopirapone; Metroprione; Methapyrapone; Metyrapon; Methopyrinine; Methopyrone; 2-methyl-1,2-dipyridin-3-ylpropan-1-one; 2-Methyl-1,2-di(pyridin-3-yl)propan-1-one; Methopyrapone; 2-Methyl-1,2-di(3-pyridinyl)-1-propanone; 2-méthyl-1,2-dipyridin-3-ylpropan-1-one; 2-Methyl-1,2-dipyridin-3-ylpropan-1-on |
| Molecular Formula | C14H14N2O |
| Molecular Weight | 226.27 |
| Purity | 96 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 384.4±22.0 °C at 760 mmHg |
| Melting Point | 52-55 °C (lit.) |
| Appearance | powder |
| Water Solubility | H2O: soluble (sparingly) |
| Storage Condition | Store at +4°C |
| Application | Metyrapone inhibits P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. |
| EINECS | 200-206-2 |
| HTC | 2933399090 |
| PubChem ID | 24888424 |
| MDL Number | MFCD00006397 |
| SMILES | CC(C)(c1cccnc1)C(=O)c2cccnc2 |
| InChI | 1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3 |
| InChI Key | FJLBFSROUSIWMA-UHFFFAOYSA-N |
| Beilstein/REAXYS | 163023 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| MSDS | msds/11425_1_54_36_4.pdf |
| Bioactivity | Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.Target: CYP11B1Metyrapone is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-Deoxycortisol levels. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 384.4±22.0 °C at 760 mmHg Melting Point 53-56ºC Molecular Formula C14H14N2O Molecular Weight 226.274 Flash Point 189.3±28.8 °C Exact Mass 226.110611 PSA 42.85000 LogP 1.19 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.565 Storage condition Store at +4°C Water Solubility H2O: soluble (sparingly) |
| Use of | Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.Target: CYP11B1Metyrapone is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-Deoxycortisol levels. Properties Articles63 Name metyrapone Synonym More Synonyms metyrapone Biological Activity Description Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.Target: CYP11B1Metyrapone is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-Deoxycortisol levels. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease Chemical & Physical Properties Molecular Formula C14H14N2O Exact Mass 226.110611 PSA 42.85000 Index of Refraction 1.565 Water Solubility H2O: soluble (sparingly) |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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