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Home > Products > Specialty & Industrial Chemicals > Industrial Applications > 2-(2-(2-(2-AMINOETHOXY)ETHOXY)ETHOXY)ETHANOL
2-(2-(2-(2-AMINOETHOXY)ETHOXY)ETHOXY)ETHANOL structure, CAS 86770-74-3

2-(2-(2-(2-AMINOETHOXY)ETHOXY)ETHOXY)ETHANOL

CAS Number86770-74-3

Synonyms2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethanol; 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol

Molecular FormulaC8H19NO4

Molecular Weight193.24

Purity96+%

Density1.1±0.1 g/cm3

Boiling Point301.6±27.0 °C at 760 mmHg

Melting Point

Flash Point

AppearanceLight yellow oily

EINECS0

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-0202221 Purity: 96+%
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Quality Control of [ 86770-74-3 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number86770-74-3
Catalog No.2A-0202221
Chinese Name1-氨基-3,6,9-三噁-11-十一醇
Synonyms2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethanol; 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol
Molecular FormulaC8H19NO4
Molecular Weight193.24
Purity96+
Density1.1±0.1 g/cm3
Boiling Point301.6±27.0 °C at 760 mmHg
AppearanceLight yellow oily
Storage Condition2-8℃, dry and well ventilated
ApplicationAmino-PEG4-alcohol is a PEG-based PROTAC linker that can be used to synthesize PROTAC. Amino-PEG4-alcohol is also a nondegradable ADC linker for the synthesis of antibody drug conjugates (ADC).
EINECS0
HTC2922509090
UN(IATA)0
PubChem ID329823900
MDL NumberMFCD01752874
SMILESNCCOCCOCCOCCO
InChIInChI=1S/C8H19NO4/c9-1-3-11-5-7-13-8-6-12-4-2-10/h10H,1-9H2
InChI KeyANOJXMUSDYSKET-UHFFFAOYSA-N
NACRES CodeNA.22
UNSPSC51171641
BioactivityAmino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs Non-cleavable In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. References [1]. Nello Mainolfi, et al. Protein degraders and uses thereof. WO2019060742A1. [2]. Miller MA, et al. Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 Dec 26;12(12):12814-12826. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 301.6±27.0 °C at 760 mmHg Molecular Formula C8H19NO4 Molecular Weight 193.241 Flash Point 136.2±23.7 °C Exact Mass 193.131409 PSA 73.94000 LogP -2.09 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.459 InChIKey ANOJXMUSDYSKET-UHFFFAOYSA-N SMILES NCCOCCOCCOCCO
Use ofAmino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Properties Name 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol Synonym More Synonyms Amino-PEG4-alcohol Biological Activity Description Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. References [1]. Nello Mainolfi, et al. Protein degraders and uses thereof. WO2019060742A1. [2]. Miller MA, et al. Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 Dec 26;12(12):12814-12826. Chemical & Physical Properties Molecular Formula C8H19NO4 Exact Mass 193.131409 PSA 73.94000 LogP -2.09 Index of Refraction 1.459 InChIKey ANOJXMUSDYSKET-UHFFFAOYSA-N SMILES NCCOCCOCCOCCO
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